Contributions of polymorphisms in miR146a, miR196a, and miR499 to the development of hepatocellular carcinoma

Lh, Zhang; Bb, Hao; Cy, Zhang; Xz, Dai; Zhang, F

doi:10.4238/gmr.15038582

Cited by 17 publications

(14 citation statements)

References 27 publications

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“…However, this study did not show genetic association of rs3746444 polymorphism with periodontitis. These results are similar to studies conducted in Chinese population, showing lack of association of this polymorphism with hepatocellular carcinoma and ischaemic stroke, though the miR‐499 was earlier reported to be involved in cancer and heart diseases (Zhang, Hao, Zhang, Dai, & Zhang, 2016; Zhu, Hou, Ma, Yang, & Pan, 2018). Thus, finding out the association of miR‐499 polymorphisms with periodontitis opens up the possibility of understanding the aetiopathogenesis of inflammatory disease like periodontitis, formulating proper treatment modalities and preventive measures.…”

Section: Discussionsupporting

confidence: 90%

Association analysis of miR‐499 rs3746444 gene polymorphism with periodontitis

Kaarthikeyan

Jayakumar

Anand

2020

Int J Immunogenetics

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Background and Objective Periodontitis is a chronic inflammatory disease. The innate immune mechanism plays a significant role in the aetiopathogenesis of periodontal destruction. The innate immune signalling molecular factors are regulated by small noncoding RNAs called microRNAs (miRNAs). miR‐499 targets many inflammatory cytokine gene mRNAs and has been associated with many inflammatory diseases like rheumatoid arthritis and cardiovascular diseases. Single nucleotide polymorphisms (SNPs) are found to be genetic factors of periodontitis. Not much information is available on miRNA SNP and periodontitis. Thus, the aim of the present study was to find the association of miR‐499 rs3746444 gene polymorphism with chronic periodontitis, aggressive periodontitis and healthy controls. Materials and methods This is a case–control study and includes 80 aggressive periodontitis cases, 81 chronic periodontitis cases and 167 healthy controls. DNA extraction was extracted from the peripheral blood lymphocytes, and the PCR amplification of rs3746444 region of miR‐499 gene was done. The amplified products were restriction‐digested using the enzyme Bcl1. The restriction‐digested products were analysed by electrophoresis on a 3% agarose gel. Results Our study results showed no significant association of genotypes of miR‐499 rs3746444 with chronic periodontitis (OR 0.91, CI = 0.39–2.01 and p = .813) and aggressive periodontitis in this study population (OR 0.38, CI = 0.12–1.02 and p = .054). The C allele of rs3746444 could be a protective allele in the susceptibility to aggressive periodontitis (OR 0.64; 95% CI = 0.42–0.99; p = .043). There was no significant association of chronic periodontitis as far as miR‐499 rs3746444 genotypes were concerned. Conclusion Our study concludes that there is no significant association of miR‐499 rs3746444 polymorphism with periodontitis in this study population.

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Section: Discussionsupporting

confidence: 90%

Association analysis of miR‐499 rs3746444 gene polymorphism with periodontitis

Kaarthikeyan

Jayakumar

Anand

2020

Int J Immunogenetics

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“…Of the 65 studies, sample sizes ranged from 175 to 3,585, and publication year ranged from 2009 to 2017. In total, there were 2 acute lymphoblastic leukemia studies (Gutierrez-Camino et al, 2014 ; Hasani et al, 2014 ), 10 breast cancer studies (Hu et al, 2009 ; Catucci et al, 2010 ; Alshatwi et al, 2012 ; Bansal et al, 2014 ; Omrani et al, 2014 ; He et al, 2015 ; Qi et al, 2015 ; Dai et al, 2016 ; Afsharzadeh et al, 2017 ), 3 bladder cancer studies (Mittal et al, 2011 ; Deng et al, 2015 ; Wang et al, 2016 ), 5 colorectal cancer studies (Min et al, 2012 ; Vinci et al, 2013 ; Hu et al, 2014 ; Dikaiakos et al, 2015 ; Ying et al, 2016 ), 2 cervical squamous cell carcinoma studies (Zhou et al, 2011 ; Srivastava et al, 2017 ), 3 esophageal cancer studies (Umar et al, 2013 ; Wei et al, 2013 ; Shen et al, 2016 ), 7 gastric cancer studies (Okubo et al, 2010 ; Ahn et al, 2013 ; Wu et al, 2013 ; Pu et al, 2014 ; Cai et al, 2015 ; Poltronieri-Oliveira et al, 2017 ; Rogoveanu et al, 2017 ), 17 hepatocellular carcinoma studies (Akkiz et al, 2011 ; Kim et al, 2012 ; Xiang et al, 2012 ; Zhou et al, 2012 , 2014 ; Shan et al, 2013 ; Zou and Zhao, 2013 ; Chu et al, 2014 ; Hao et al, 2014 ; Kou et al, 2014 ; Ma et al, 2014 ; Qi et al, 2014 ; Wang et al, 2014 ; Li D. et al, 2015 ; Li X. et al, 2015 ; Yan et al, 2015 ; Zhang et al, 2016 ), 4 lung cancer studies (Tian et al, 2009 ; Vinci et al, 2011 ; Li D. et al, 2016 ), 2 oral squamous cell cancer studies (Hou et al, …”

Section: Resultsmentioning

confidence: 99%

“…Wang et al ( 2014 ) found that miR-499A>G polymorphism is associated with an increased risk of hepatocellular carcinoma in Chinese individuals. However, Zhang et al ( 2016 ) suggested that there is no association between miR-499 variant and the risk of hepatocellular carcinoma in the co-dominant, dominant, and recessive models. These two articles similarly focus on hepatocellular carcinoma, but it led to very different results.…”

Section: Introductionmentioning

confidence: 99%

A Meta-Analysis of miR-499 rs3746444 Polymorphism for Cancer Risk of Different Systems: Evidence From 65 Case-Control Studies

Yang

Zhou

2018

Front. Physiol.

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MicroRNAs (miRNAs) are a class of endogenous, short and non-coding RNAs that may play important roles in the pathogenesis of tumor. The associations between microRNA-499 rs3746444 polymorphism and cancer risk in different systems remain inconclusive. This article is aimed to obtain more exact estimation of these relationships through a meta-analysis based on 52,456 individuals. We retrieved relevant and eligible studies from Pubmed and Embase database up to January 10, 2018. ORs and 95% CIs were used to estimate the associations between miR-499 polymorphism and cancer susceptibility in different systems. All analyses were performed using the Stata 11.0 software. A total of 65 case-control studies were retrieved using explicit inclusion and exclusion criteria. The study included 23,762 cases and 28,694 controls. Overall cancer analysis showed the association between miR-499 polymorphism and susceptibility to cancer was significant. MicroRNA-499 rs3746444 was found to be significantly associated with increased risk of cancer of the respiratory system (CC vs. TT: OR = 1.575, 95% CI = 1.268–1.955, CC vs. TC+TT: OR = 1.527, 95% CI = 1.232–1.892), digestive system (CC vs. TT: OR = 1.153, 95% CI = 1.027–1.295; TC vs. TT: OR = 1.109, 95% CI = 1.046–1.176; CC+TC vs. TT: OR = 1.112, 95% CI = 1.018–1.216; CC vs. TC+TT: OR = 1.137, 95% CI = 1.016–1.272; C vs. T: OR = 1.112, 95% CI = 1.025–1.206), urinary system (TC vs. TT: OR = 1.307, 95% CI = 1.130–1.512; CC+TC vs. TT: OR = 1.259, 95% CI = 1.097–1.446; C vs. T: OR = 1.132, 95% CI = 1.014–1.264), and gynecological system (C vs. T: OR = 1.169, 95% CI = 1.002–1.364). In the subgroup analysis by ethnicity, the result showed that significant association with an increased cancer risk was found in Asian. Subgroup analysis based on type of tumor was also performed, miR-499 rs3746444 is associated with susceptibility of cervical squamous cell carcinoma, lung cancer, prostate cancer, and hepatocellular carcinoma.

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“…When the source of heterogeneity was analyzed, we found that high-quality score (≥7.0), small sample size (<1000 subjects), CRC, HCC, GC, ESCC, Asians and hospital-based study subgroups increased it greatly. Additionally, in dominant model (Figure 2), Galbraith radial plot and the forest plot identified eleven outliers (Chae et al 2013;Dikaiakos et al 2015;Duan Lei 2017;Guo et al 2010;Kupcinskas et al 2014a;Li et al 2015;Lv et al 2013;Ma 2012;Srivastava et al 2010;Zhang et al 2016).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, we used Galbraith radial plot to determine the heterogeneity ( Figure 5). Among the eligible studies, eleven outliers (Chae et al 2013;Dikaiakos et al 2015;Duan Lei 2017;Guo et al 2010;Kupcinskas et al 2014a;Li et al 2015;Lv et al 2013;Ma 2012;Srivastava et al 2010;Zhang et al 2016) were found, which contributed to the main heterogeneity.…”

Section: Heterogeneitymentioning

confidence: 99%

MiRNA-146a rs2910164 Confers a Susceptibility to Digestive System Cancer: A Meta-Analysis Involving 59,098 Subjects

Chen

et al. 2020

Immunological Investigations

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Background: MicroRNA (miR)-146a might participate in the occurrence of malignant tumor. The aim of the current investigation was to evaluate the relationship of microRNA-146a (miR-146a) rs2910164 C > G locus to the development of digestive system cancer (DSC). Methods: We retrieved publications from PubMed, China Biology Medicine and EMBASE databases up to August 29, 2019. Finally, 56 independent case-control studies with 59,098 participants were included. The strength of the relationship between rs2910164 locus and a risk of DSC was assessed. The power value was also calculated in this study. Results: We identified a correlation of rs2910164 locus in miR-146a with DSC development in dominant model (P = .035; power value = 0.994). MiR-146a rs2910164 locus was also identified to be correlated with a risk of DSC in Asians (GG/CG vs. CC: P = .033; power value = 0.989). Sensitivity analysis revealed that any individual study could not alter the final decision. In our study, no significant bias was found among these included studies (P > .1). The results of heterogeneity analysis suggested that small sample size (<1000 subjects), colorectal carcinoma, Asians, gastric carcinoma, esophageal squamous cell carcinoma, hepatocellular cancer, hospital-based study and highquality score (≥7.0) subgroups contributed the heterogeneity to our findings. Galbraith radial plot determined that eleven outliers contributed to the main heterogeneity. Conclusion: In summary, this meta-analysis highlights that rs2910164 locus might be implicated in the risk of DSC. More studies are, therefore, needed to confirm our results.

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Contributions of polymorphisms in miR146a, miR196a, and miR499 to the development of hepatocellular carcinoma

Cited by 17 publications

References 27 publications

Association analysis of miR‐499 rs3746444 gene polymorphism with periodontitis

Association analysis of miR‐499 rs3746444 gene polymorphism with periodontitis

A Meta-Analysis of miR-499 rs3746444 Polymorphism for Cancer Risk of Different Systems: Evidence From 65 Case-Control Studies

MiRNA-146a rs2910164 Confers a Susceptibility to Digestive System Cancer: A Meta-Analysis Involving 59,098 Subjects

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