Contributions of the receptor for advanced glycation end products axis activation in gastric cancer

Rojas, Armando; Lindner, Cristian; Schneider, Iván; González, Ileana; Morales, Miguel A.

doi:10.3748/wjg.v29.i6.997

Cited by 8 publications

(8 citation statements)

References 137 publications

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“…It is noteworthy that chondroitin sulfate has been confirmed as a ligand for the receptor for advanced glycation end products (RAGE) ( 29 ), and the role of RAGE in tumor biology is increasingly prominent, particularly in the field of gastric cancer research. The activation status of RAGE is closely associated with its mediation of tumor cell proliferation, enhanced invasive capacity, increased metastatic potential, and poor prognosis in gastric cancer patients ( 30 ). These studies further confirm that CHSY3 plays an important role in the development of malignant phenotypes in gastric cancer.…”

Section: Discussionmentioning

confidence: 99%

The prognostic implications and tumor-promoting functions of CHSY3 in gastric cancer

Wang,

Zhang,

Wei

et al. 2024

Front. Immunol.

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Chondroitin sulfate synthase 3 (CHSY3) is an important enzyme that regulates glycosylation, but its role in tumors has not been determined. Here, we showed that high CHSY3 expression promotes proliferation in gastric cancer (GC) cells and is associated with poor prognosis in GC patients. We analyzed the immunohistochemistry data of 150 gastric cancer patients to determine the clinicopathological and survival significance of CHSY3. Immunofluorescence was used to detect the colocalization of CHSY3 with infiltrating immune cells. Additionally, CHSY3 was predominantly found in tumor tissues and showed higher abundance compared to matched adjacent tissues. High CHSY3 expression was associated with more advanced tumor stage, higher recurrence risk and worse survival. Immunohistochemistry and bioinformatic analysis revealed that CHSY3 expression was significantly positively correlated with tumor-associated macrophage (TAM) infiltration. Moreover, after knocking down CHSY3, the proliferation of cells was decreased, and the migration ability was reduced, as shown by scratch, monoclonal and transwell assays. In conclusion, this study revealed that CHSY3 has a tumor-promoting effect on GC, suggesting a novel therapeutic strategy against this disease.

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Section: Discussionmentioning

confidence: 99%

The prognostic implications and tumor-promoting functions of CHSY3 in gastric cancer

Wang,

Zhang,

Wei

et al. 2024

Front. Immunol.

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“…WJG v29i6: I like the following three review articles: (1) Gastric cancer topic: “Contributions of the receptor for advanced glycation end products axis activation in gastric cancer[ 16 ]”, because it is novel and has potential for practically impacting translational research; (2) Rectal cancer topic: “Implications of recent neoadjuvant clinical trials on the future practice of radiotherapy in locally advanced rectal cancer”[ 17 ]; and (3) Hepatocellular carcinoma topic: “Immunotherapy for hepatocellular carcinoma: Current status and future perspectives”[ 18 ].…”

Section: Hot Articles and Insufficient Articlesmentioning

confidence: 99%

Editor-in-Chief articles of choice and comments at the year-end of 2023

Tarnawski

2024

World J Gastroenterol

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As the Editor-in-Chief, every week prior to a new issue’s online publication, I perform a careful review of all encompassed articles, including the title, clinical and/or research importance, originality, novelty, and ratings by the peer reviewers. Based on this review, I select the papers of choice and suggest pertinent changes (e.g. , in the title) to the Company Editors responsible for publication. This process, while time-consuming, is very important for assuring the quality of publications and highlighting important articles that Readers may revisit.

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“…Notwithstanding, we have focused on the relationship between dietary AGEs and oral, esophageal, and gastric epithelial cells [ 1 ]. RAGE is expressed on oral [ 79 , 80 ], esophageal [ 81 ], and gastric epithelial cells [ 82 ], and TLR4 is expressed on oral [ 83 ], esophageal [ 84 ], and gastric epithelial cells [ 85 ]. Because these epithelial cell types are exposed to air and direct physical contact with dietary AGEs, the dietary AGEs-RAGE/TRL4 axis may appear.…”

Section: Intra-/extracellular Ages and Lsrdsmentioning

confidence: 99%

Analysis of Crude, Diverse, and Multiple Advanced Glycation End-Product Patterns May Be Important and Beneficial

Takata,

Masauji,

Motoo

2023

Metabolites

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Lifestyle-related diseases (LSRDs), such as diabetes mellitus, cardiovascular disease, and nonalcoholic steatohepatitis, are a global crisis. Advanced glycation end-products (AGEs) have been extensively researched because they trigger or promote LSRDs. Recently, techniques such as fluorimetry, immunostaining, Western blotting, slot blotting, enzyme-linked immunosorbent assay, gas chromatography-mass spectrometry, matrix-assisted laser desorption-mass spectrometry (MALDI-MS), and electrospray ionization-mass spectrometry (ESI-MS) have helped prove the existence of intra/extracellular AGEs and revealed novel AGE structures and their modifications against peptide sequences. Therefore, we propose modifications to the existing categorization of AGEs, which was based on the original compounds identified by researchers in the 20th century. In this investigation, we introduce the (i) crude, (ii) diverse, and (iii) multiple AGE patterns. The crude AGE pattern is based on the fact that one type of saccharide or its metabolites or derivatives can generate various AGEs. Diverse and multiple AGE patterns were introduced based on the possibility of combining various AGE structures and proteins and were proven through mass analysis technologies such as MALDI-MS and ESI-MS. Kampo medicines are typically used to treat LSRDs. Because various compounds are contained in Kampo medicines and metabolized to exert effects on various organs or tissues, they may be suitable against various AGEs.

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Contributions of the receptor for advanced glycation end products axis activation in gastric cancer

Cited by 8 publications

References 137 publications

The prognostic implications and tumor-promoting functions of CHSY3 in gastric cancer

The prognostic implications and tumor-promoting functions of CHSY3 in gastric cancer

Editor-in-Chief articles of choice and comments at the year-end of 2023

Analysis of Crude, Diverse, and Multiple Advanced Glycation End-Product Patterns May Be Important and Beneficial

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