Contributions of undernutrition and handling to huddling development of rats

Soriano, Ofelia; Regalado, Mirelta; Torrero, Carmen; Salas, Manuel

doi:10.1016/j.physbeh.2006.07.021

Cited by 12 publications

(10 citation statements)

References 61 publications

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“…The current findings agree with previous studies showing that perinatal undernourishment consistently interferes with the physical development of newborns and adults, and that food deprivation, which is usually associated with a deficiency of sensory stimulation, reduces body weight gain. [44][45][46]50 However, the significant increase in body weight at 7 and 12 days of age between CG and CHG rats indicates that early sensory stimulation here used was able to modify the body weight of subjects. Pups of all experimental groups received sensory stimulation during the mother-litter encounter in the living cage, 49 and it is known that this maternal stimulation has an ameliorating effect on adverse behavioral responses to stress in the offspring; however, its role in physical development and early olfactory discrimination is under investigation.…”

Section: Discussionmentioning

confidence: 77%

“…[31][32][33][34][35] Furthermore, increases in the quality and/or quantity of handling given to the pups may improve anatomical, electrophysiological, and long-term adaptive behavioral responses. 28,[36][37][38][39][40][41][42][43][44] In the rat, early handling has been used as a tool to attenuate morphological and behavioral damages associated with perinatal undernourishment and sensory deprivation. 41,45,46 The heart rate-orienting response to a new odor paradigm has been used to investigate the development of fine odor discrimination in infant rats.…”

Section: Introductionmentioning

confidence: 99%

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Perinatal undernourishment and handling: effects on olfactory discrimination in the newborn rat

Ruiz-Diaz

Torrero

Regalado

et al. 2010

Nutritional Neuroscience

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The heart rates of rats aged 4, 7, and 12 days were recorded for control (CG), undernourished (UG), control-handled (CHG), and undernourished-handled (UHG) groups after exposure to amyl acetate and menthol. Pregnant dams were undernourished and received 50% of a balanced diet from gestational day (G) 6 to G12, 60% from G13-G18, and 100% from G19-G21. On postpartum days 0-12, pups remained for 12 h with a normal and 12 h with a nipple-ligated dam. The pups were handled 5 min daily on days 1-12 of age to ameliorate the stress from undernourishment. Basal heart rate, heart rate habituation, and the discrimination to a second odor were evaluated. Body weight of UG and UHG rats was significantly reduced. Basal heart rate gradually increased with age, especially in the CHG, without changes in the UHG; habituation was present and odor discrimination was modified by the diet and handling. These data indicate that olfactory discrimination is present at birth, and undernourishment does not impair but handling modifies its functionality.

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Section: Discussionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

Perinatal undernourishment and handling: effects on olfactory discrimination in the newborn rat

Ruiz-Diaz

Torrero

Regalado

et al. 2010

Nutritional Neuroscience

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“…This is a relevant finding because the UG animals maintain their capacity to gain experience through associative learning, and to revert the cognitive deficiencies commonly associated with perinatal undernutrition, by the combination of food and early sensory rehabilitation [5,6,33,[47][48][49]. However, further studies are required to test that in the wild life these mechanisms are over expressed as in the case of UG subjects, surrounded by an environmental condition that frequently elicits stressful responses.…”

Section: Discussionmentioning

confidence: 99%

“…In the past, a number of studies have shown that perinatal undernutrition in the rat delays the maturation of sensory systems and causes the expression of altered motor patterns; these effects lead to a significant deficiency of somatosensory, auditory, visual, and chemosensory stimulation that may be essential for long-term behavioral performance [1][2][3][4][5][6][7][8]. Perinatal undernutrition mainly interferes with the anatomical organization of central nervous system (CNS) areas which undergo a phase of postnatal cell proliferation; these areas include the cerebral and cerebellar cortices, the hippocampus, central amygdaloid nucleus, olfactory bulb, and solitary tract nucleus, and they participate in the head movements, mouth opening and closing, chewing, food ingestion, and chemosensory CNS integration [8,[9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Development of the Gusto Facial Reflex in Perinatally Undernourished Rats

Salas¹,

Torrero²,

Regalado³

et al. 2012

JBBS

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In the rat, the taste system plays a critical role in motivating the animal to consume nutrients and avoid toxic substances. In neonatal rat the orofacial movements can be modified by the application of sucrose and quinine in the mouth, producing ingestion or rejection responses, respectively, but there is no information available on the gusto facial reflexes (GFR) under perinatal fasting. The aim of the present study was to determine how undernutrition can affect the development of orofacial responses to sucrose, quinine, and NaCl during early development. Pregnant dams were undernourished by being given 50% of a balanced diet from G6 to G12, 60% from G13 -G18, and 100% from G 19-G21. On postpartum days 0 -9, prenatally underfed (UG) pups continued the undernourishment by remaining for 12 h with a foster dam and 12 h with a nipple-ligated mother. Stimuli were presented as a single droplet of sucrose (S), sodium chloride (NaCl), quinine hydrochloride (Q), and water (W) onto the lips at 1, 3, 5, 7, and 9 days of age, and mouth-opening frequency (MO) and lip-licking frequency (LL) were analyzed. The results show consistent effects associated with age, but not with diet, except in the cases of 0.01 M Q, which provoked in the UG subjects increased MO and the reduction of LL, and 0.1 M Q, which consistently reduced both responses. Moreover, S provoked increases in both MO and LL at 0.1 M while NaCl and water elicited minimal effects on GFR. These data suggest that perinatal undernutrition affects the basic components of the gustatory system necessary to produce GFR in the first postnatal days by possibly interfereing with the integration of taste input for food learning and the hedonic aspects of gustatory cues.

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“…During lactation, neonatally underfed F1 young interact poorly with their F0 mothers and littermates, and the somatosensory cues of the mother decrease significantly[31] …”

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confidence: 99%

Juvenile Play Behavior in Neonatally Underfed and Sensory Stimulated Wistar Rats

Salas¹,

Regalado²,

Torrero³

et al. 2019

JBBS

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Play development in juvenile rats depends on specific sensory signals integrated at cortical, limbic and brain stem levels to modulate motoric, metabolic, motivational and social responses. Neonatal undernourishment disrupts the morphological and functional organization of the brain for adaptive responses including play performance. These alterations may be restored by preweaning exposure to sensory-enriched environments. This study was designed to determine in four experimental groups, Control (LC), Underfed (LU), Control Ligated/Stimulated (LCS), and Underfed Ligated/Stimulated (LUS), whether changes in juvenile play of neonatally underfed male rats by the nipple-ligated procedure of F0 dams and/or the handling of F1 rats may restore the deficiencies in juvenile play performance. The pinning frequency values in LC, LCS and LUS groups consistently increased until reaching a significant peak between postnatal days (PDs) 25 and 50 and then gradually declining until PD 60, when the play in pairs was significantly higher compared with the play in groups that follows the same sequence but with lower values in the stimulated groups. The results may reflect poor maternal care and lower somatosensory stimulation; and the sensory massage of LU F1 pups compared with the LC, LUS, and LCS rats. Fewer dorsal body contacts occurred in LU and LUS rats when playing in pairs than in groups. Results suggest that although handling has salutary effects on neuronal play structures, the reduced levels of total pinning and dorsal contacts, mainly in the play of rat pairs in LCS vs. LUS groups, were not fully recovered.

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Contributions of undernutrition and handling to huddling development of rats

Cited by 12 publications

References 61 publications

Perinatal undernourishment and handling: effects on olfactory discrimination in the newborn rat

Perinatal undernourishment and handling: effects on olfactory discrimination in the newborn rat

Development of the Gusto Facial Reflex in Perinatally Undernourished Rats

Juvenile Play Behavior in Neonatally Underfed and Sensory Stimulated Wistar Rats

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