Contributors

Ahmed, Tanveer; Baranwal, Gaurav; Bebortta, Sujit; Bharti, Vandana; Biswas, Bhaskar; Chaube, Mithilesh Kumar; Chaudhary, Ankit; Gupta, P.K.; Jayashankara, M.; Kumar, Abhinav; Kumar, Dinesh; Kumar, Santosh; Kumar, Sunil; Manjari, Kanak; Maurya, Ashish Kumar; Mishra, Prerna; Murria, Saniksha; Pandey, Anil Kumar; Raheja, Jagdish Lal; Sandhu, Rajinder; Saxena, Sonal; Senapati, Dilip; Sharma, Anil Kumar; Sharma, Anshul; Sharma, Ritesh Kumar; Shrivastava, Sameer; Shukla, K. K.; Singal, Gaurav; Singh, Ravi Shankar; Das, Subir; Singh, Sanjay Kumar; Singh, Rajesh; Tandon, Righa; Tiwari, Shrikant; Udmale, Sandeep S.; Varshney, Shefali; Verma, Madhushi; Verma, Rohit; Yadav, Rimmy

doi:10.1016/b978-0-12-821472-5.09994-4

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“…In the present study, histological changes observed in the liver, kidney, and pancreas in STZ-induced diabetic rats were similar to previous findings of Usman et al 43 and Ahmed et al 61 Apoptosis in hepatic cells, hemorrhage in the central vein, congested sinusoidal spaces, and congestion in the central vein were seen in the liver segment of the diabetic group. The insulin treated and camel milk treated groups showed improvements in all these changes.…”

Section: ■ Discussionsupporting

confidence: 92%

Comparative Attenuating Impact of Camel Milk and Insulin in Streptozotocin-Induced Diabetic Albino Rats

Raj,

Shuklan,

Madan

et al. 2023

ACS Omega

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In this study, albino Wistar rats that have developed diabetes as a result of the drug streptozotocin (STZ) were treated with camel milk and insulin. For this, 36 rats were divided into six different (n = 6) groups: control, control + camel milk, diabetic control, insulin, camel milk, and combined camel milk + insulin. A 50 mg/kg intraperitoneal injection of STZ was used to induce diabetes. Rats with blood glucose levels exceeding 250 mg/dL after the induction of diabetes were taken into consideration for the study. The diabetic rats were treated with camel milk (50 mL/rat/day), insulin (6 units kg −1 b•wt/ day), or their combination daily for 30 days. Throughout the course of the study, the rats' glucose levels and body weight were checked. In the diabetic control rats, a reduction in body weight and hyperglycemic condition was seen. Improvements in glycemic levels and weight gain were seen in the camel milk, insulin, and combined treatment groups compared to the diabetic control group; however, the combined treated group did not show the same degree of improvement as the alone treated group. Hematological changes in the diabetic control group included reductions in lymphocytes, platelets, total leukocyte count (TLC), and red blood cell (RBC) indices (mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), packed cell volume (PCV), and mean cell hemoglobin concentration (MCHC)). Each group that got insulin and camel milk separately and combined showed improvement in these changes. The liver, kidney, and pancreas in the diabetic control group had worsened morphological alterations. These histopathological alternations were significantly improved in the treatment groups. Hence, this study demonstrates the antidiabetic effects of camel milk in comparison to insulin. These findings highlight the potential of camel milk as an alternative therapy for diabetes, although further research is warranted to fully understand its mechanisms of action and long-term effects.

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Section: ■ Discussionsupporting

confidence: 92%