Contributors to cognitive impairment in congestive heart failure: a pilot case–control study

Beer, Christopher; Ebenezer, Esther Gunaseli M.; Fenner, Stephen; Lautenschlager, Nicola T.; Arnolda, Leonard F; Flicker, Leon; Almeida, Osvaldo P.

doi:10.1111/j.1445-5994.2008.01790.x

Cited by 51 publications

(60 citation statements)

References 34 publications

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“…Furthermore, greater WMHs were independently associated with reduced global cognition, demonstrated by lower scores on Mini Mental Status Examinations. Beer et al [32] had similar findings in a study comparing CHF and non-CHF patients without clinically significant cognitive impairment. A moderate association was found between cognitive scores, determined by the CAMCOG test, and deep matter white hyperintensities along with left medial temporal atrophy in CHF patients.…”

Section: Role Of Imagingmentioning

confidence: 54%

Heart failure and cognitive dysfunction

Ampadu

Morley

2015

International Journal of Cardiology

149

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Section: Role Of Imagingmentioning

confidence: 54%

Heart failure and cognitive dysfunction

Ampadu

Morley

2015

International Journal of Cardiology

149

View full text Add to dashboard Cite

“…Of note is that the patients also revealed more symptoms of depression and anxiety, which may partly explain results 29. Compared with healthy controls, patients with systolic heart failure showed significantly lower scores on several cognitive domains 25. In two other studies including patients with cardiovascular disease, those with systolic heart failure showed verbal memory deficits and executive functions deficits, such as cognitive inflexibility 27 28.…”

Section: Specific Cognitive Deficits In Patients With Cardiac Diseasementioning

confidence: 90%

Cardiac disease and cognitive impairment: a systematic review

Eggermont

Boer

Muller

et al. 2012

Heart

155

108

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Cognitive impairment in cardiac patients may interfere with disease management. This review describes studies examining specific cognitive impairments in cardiac patients and studies that investigate the link between echocardiographic and cognitive measures. Executive function impairments were frequently reported in different patient groups. Also, lower cardiac output and worse left ventricular diastolic function are linked to executive function deficits. In cardiac patients, special attention should be paid to these executive function impairments in view of their role in disease management and independent living. Interventions that stimulate executive function should be encouraged and integrated in cardiac treatment protocols.

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“…Possible mechanisms for cognitive dysfunction in heart failure include systemic hypoperfusion [19,20,40,45,47], cerebral hypoperfusion [39], cardiogenic emboli [41,48], cerebral infarcts [39], biochemical alterations (e.g. in serum concentrations of renin, aldosterone, sodium and potassium) [49,50] and endothelial abnormalities [21,51,52]. …”

Section: Discussionmentioning

confidence: 99%

Longitudinal Trajectories of Cognitive Decline among Older Adults with Cardiovascular Disease

Okonkwo

Cohen²,

Gunstad

et al. 2010

Cerebrovasc Dis

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Background: The long-term course of cognitive impairments secondary to cardiovascular disease (CVD) is unclear. In this study, we prospectively investigated the temporal pattern, rate and hierarchy of cognitive decline attributable to CVD – a risk factor for the development of vascular cognitive impairment (VCI) – and examined the influence of cardiac surgery and heart failure on cognitive decline. Methods: A total of 172 older adults with CVD were administered a comprehensive battery of neuropsychological tests at study entry, and at 12 and 36 months thereafter. Random coefficient regressions were used to investigate the temporal course, rate and hierarchy of cognitive decline, as well as to examine the effect of heart failure (reported by 21% of the sample) and cardiac surgery (reported by 44% of the sample) on trajectories of cognitive change. Results: The course of decline in cognition was linear for language and attention-executive function-psychomotor speed, and curvilinear for visuospatial abilities, memory and overall cognition. The decline in attention-executive function-psychomotor speed was smaller than the decline in other domains. The greatest decline occurred in visuospatial abilities. The rate of decline in cognition was not altered by a history of heart failure. Patients who had undergone cardiac surgery exhibited slower deceleration in their rates of decline in overall cognition. At baseline, patients with a history of heart failure had comparatively poorer attention-executive function-psychomotor speed, overall cognition and, to a lesser extent, visuospatial scores. Conclusion: There is measurable decline in neurocognitive function among patients with CVD. This decline is linear in some cognitive domains and curvilinear in others and is not attributable to the normal aging process. Cardiac surgery, but not heart failure, significantly affects the trajectory of cognitive decline. Because most vascular risk factors are modifiable, preventive measures such as lifestyle changes may be useful in retarding cognitive decline among patients with CVD, thus preventing the onset of VCI.

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Contributors to cognitive impairment in congestive heart failure: a pilot case–control study

Cited by 51 publications

References 34 publications

Heart failure and cognitive dysfunction

Heart failure and cognitive dysfunction

Cardiac disease and cognitive impairment: a systematic review

Longitudinal Trajectories of Cognitive Decline among Older Adults with Cardiovascular Disease

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