2001
DOI: 10.1053/ajkd.2001.24515
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Contributory metabolic factors in the development of nephrolithiasis in patients with medullary sponge kidney

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Cited by 31 publications
(28 citation statements)
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“…Hypercalcuria was present in 21% of 24 stone-forming patients with MSK in our series. Likewise, there are differences in reported prevalence of hyperoxaluria in MSK patients, from 0% of 17 patients [14] to 45% of 22 [13] , compared with our finding of hyperoxaluria in 17% of 24 patients. Local dietary factors, such as a low calcium and high oxalate diet seen in the Japanese population, may account for the data published by Yagisawa et al [13] .…”
Section: Discussioncontrasting
confidence: 96%
See 1 more Smart Citation
“…Hypercalcuria was present in 21% of 24 stone-forming patients with MSK in our series. Likewise, there are differences in reported prevalence of hyperoxaluria in MSK patients, from 0% of 17 patients [14] to 45% of 22 [13] , compared with our finding of hyperoxaluria in 17% of 24 patients. Local dietary factors, such as a low calcium and high oxalate diet seen in the Japanese population, may account for the data published by Yagisawa et al [13] .…”
Section: Discussioncontrasting
confidence: 96%
“…Hypercalcuria is a common finding in stone-forming patients with MSK. Previous studies have reported a wide range of prevalence, from 9% of 22 patients [13] , 34% of 35 patients [5] through to 88% of 17 patients [14] . Hypercalcuria was present in 21% of 24 stone-forming patients with MSK in our series.…”
Section: Discussionmentioning
confidence: 98%
“…However, a subset of MSK patients are clinically silent [2] and the diagnosis is incidentally picked up on renal imaging for other indications. The strong association of MSK with nephrolithiasis, especially calcium stones [12], is explained by the tendency of urinary stasis in the ectatic collecting ducts and the association of high quantities of stone promoters like hypercalciuria [13] and reduced levels of inhibitors like citrate and magnesium [14] in the urine. The presence of high urinary pH (due to dRTA) can specifically increase the risk for calcium phosphate precipitation and stone formation [6], and phosphate stones are seen more frequently than oxalate [13].…”
Section: Introductionmentioning
confidence: 99%
“…This stagnant flow in dilated intramedullary collecting duct and particularly in cysts, predisposes to infection. In addition to such anatomic abnormalities, low levels of urinary inhibitors of stones seem to contribute to the pathogenesis of nephrolithiasis in patients with MSK [3]. MSK patients have defects in urinary acidification and concentration mechanism which may, in part, be the result of functional abnormality of the terminal collecting ducts [6].…”
Section: Discussionmentioning
confidence: 99%
“…The frequency of medullary sponge kidney is one case per 5000 general population, and the prevalence may be as much as 1 case per 1000 population in urology clinics. In addition, medullary sponge kidney has been identified in 12-20% of patients who form calcium stones [3]. The first sign of medullary sponge kidney is usually a UTI or a kidney stone.…”
Section: Introductionmentioning
confidence: 99%