Control Mechanisms in Delayed-Type Hypersensitivity

Turk, J.L.; Polák, L.; Parker, Darien

doi:10.1093/oxfordjournals.bmb.a071350

Cited by 66 publications

(22 citation statements)

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“…Regarding the responsiveness to DNCB the administration of CY has been shown to be able to influence the development of delayed hypersensitivity in experimental animals. Suppression and enhancement of the induction of delayed hypersensitivity have been reported, depending on the dose and schedule of the CY administered (Turk et al, 1976). It is evident that in our study the influence of CY on T-lymphocyte function was minimal.…”

Section: Discussionsupporting

confidence: 45%

Harmful effects of i.v. Corynebacterium Parvum given at the same time as cyclophosphamide in patients with squamous-cell carcinoma of the bronchus

Blomberg¹,

Glerum²,

Croles³

et al. 1980

Br J Cancer

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Summary.-The effects are reported of a combination therapy of i.v. C. parvum and cyclophosphamide on the survival time and immune responses of patients with inoperable squamous-cell carcinoma of the bronchus. The immune status of the patients was evaluated by determining the antibody response to C. parvum, the E and EAC rosettes, the PHA response of blood lymphocytes, the skin-test reactivity to Candida and PPD, the response to DNCB and the chemotaxis and NBT-dye reduction capacity of neutrophil leucocytes.The survival time of patients treated with the combination therapy was found to be significantly shorter than that of untreated patients and of those receiving cyclophosphamide only. Severe side effects were observed after C. parvum infusions, with no decrease on repeated administration. The effect of C. parvum on the different immune parameters of cyclophosphamide-treated patients was negligible, though there was a normal antibody response to C. parvum.

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Section: Discussionsupporting

confidence: 45%

Harmful effects of i.v. Corynebacterium Parvum given at the same time as cyclophosphamide in patients with squamous-cell carcinoma of the bronchus

Blomberg¹,

Glerum²,

Croles³

et al. 1980

Br J Cancer

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“…Despite the potential serious conse quences of this immunological deficit, little is known regarding its cause and pathogenesis as well as the nature of putative aggravating or alleviating factors. It has been suggested that an imbalance in immunoregulatory mech anisms may lead to a reduction of immune responsive ness in uremia possibly through increased suppressor cell activity [8][9][10][11][12], In recent years, investigations into such disorders of immunoregulation have been conducted ex tensively in mice using delayed-type hypersensitivity (DTH) test systems [13][14][15], The present study was under taken to evaluate the use of DTH skin reaction in the study of cell-mediated immunity in experimental uremia.…”

Section: Introductionmentioning

confidence: 99%

Delayed-Type Hypersensitivity Skin Reaction in the Chronically Uremic Mouse: Influence of Severity and Duration of Uremia on the Development of Response

Gagnon

1986

Nephron

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A technique of delayed-type hypersensitivity (DTH) skin reaction to a contact sensitizing agent, oxazolone, was used to assess the effects of uremia on cell-mediated immunity in chronically uremic mice and, for comparison, sham-operated and normal controls. The first objective was to establish that DTH responses are reduced in animals with renal failure. To do this, mice were made uremic by a combination of electrocoagulation of the entire surface of one kidney and subsequent contralateral nephrectomy; studies included biochemical and hematological evaluation using blood urea nitrogen level and hemoglobin concentration as routine indices to assess the degree and consequence of uremia, respectively. The second objective was to apply the technique to observe and compare changes during uremic states of varying severity and duration. A modest, although significant, decrease in both the induction and maintenance of DTH responses was observed in the mice with severe renal failure only (BUN above l00mg/dl). This immunosuppressive effect was manifest early and persisted unchanged throughout the entire observation period (3–9 weeks). This study presents new evidence that severe uremia readily produces in the mouse sustained, albeit mild, changes in cell-mediated immunity. Furthermore the ability to elicit DTH skin reaction in the chronically uremic mouse offers a versatile system for studying changes in cell-mediated immunity occurring during uremia with a broad range of potential applicability.

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“…12 In addition, there are indications for the presence of B-cells that suppress T-cells. 13 Suppressor and helper cells probably play a major role in the regulation of an immune response.…”

Section: Cell-mediated and Humoral Immune Responsementioning

confidence: 99%

Immune Suppression as Related to Toxicology

Vos

2007

Journal of Immunotoxicology

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Control Mechanisms in Delayed-Type Hypersensitivity

Cited by 66 publications

References 0 publications

Harmful effects of i.v. Corynebacterium Parvum given at the same time as cyclophosphamide in patients with squamous-cell carcinoma of the bronchus

Harmful effects of i.v. Corynebacterium Parvum given at the same time as cyclophosphamide in patients with squamous-cell carcinoma of the bronchus

Delayed-Type Hypersensitivity Skin Reaction in the Chronically Uremic Mouse: Influence of Severity and Duration of Uremia on the Development of Response

Immune Suppression as Related to Toxicology

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