2021
DOI: 10.1096/fasebj.2021.35.s1.00306
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Control of Arterial Ca V 1.2 Clustering and Coupled Gating by a Single Amino Acid

Abstract: The L‐type Ca2+ channel CaV1.2 plays key roles in cell excitability, muscle contraction and gene expression. These channels have been shown to gate in unison (e.g. coupled gating) in several cell types. CaV1.2 coupling amplifies Ca2+ influx, which can regulate cell function. In arterial myocytes, CaV1.2 coupling is increased upon elevations in extracellular glucose (HG) and in cells from diabetic patients and animal models of diabetes. Yet, the mechanisms for induction of this gating modality in CaV1.2 channel… Show more

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