Control of asparagine homeostasis inBacillus subtilis: Identification of promiscuous amino acid importers and exporters
Janek Meißner,
Manuel Königshof,
Katrin Wrede
et al.
Abstract:Amino acids are the main building block for proteins. The Gram-positive model bacteriumB. subtilisis able to import all proteinogenic amino acids from the environment as well as to synthesize them. However, the players involved in the acquisition of asparagine have not yet been identified for this bacterium. In this work, we used D-asparagine as a toxic analog of L-asparagine to identify asparagine transporters. This revealed that D-but not L-asparagine is taken up by the malate/lactate antiporter MleN. Specif… Show more
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