2017
DOI: 10.1016/j.cytogfr.2017.04.005
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Control of B lymphocyte development and functions by the mTOR signaling pathways

Abstract: Mechanistic target of rapamycin (mTOR) is a serine/threonine kinase originally discovered as the molecular target of the immunosuppressant rapamycin. mTOR forms two compositionally and functionally distinct complexes, mTORC1 and mTORC2, which are crucial for coordinating nutrient, energy, oxygen, and growth factor availability with cellular growth, proliferation, and survival. Recent studies have identified critical, non-redundant roles for mTORC1 and mTORC2 in controlling B cell development, differentiation, … Show more

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Cited by 47 publications
(60 citation statements)
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References 148 publications
(181 reference statements)
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“…RagA and RagC together with other molecules form a supercomplex at the surface of lysosomes that recruits and activates mTORC1 under nutrient sufficiency. 67 Constitutively active RagA renders mTORC1 signaling independent of the presence of amino acids and has been shown to reduce B cell competitiveness in the GC 56 (Figure 2). In contrast, expression of mutant alleles of the gene RagC that drive partial but not complete uncoupling of mTORC1 activity from amino acid dependence has been shown to boost GC expansion 68 (Figure 2).…”
Section: Me Taboli C Bal An Ce In Ac Tivated and G Erminal Center Bmentioning
confidence: 99%
“…RagA and RagC together with other molecules form a supercomplex at the surface of lysosomes that recruits and activates mTORC1 under nutrient sufficiency. 67 Constitutively active RagA renders mTORC1 signaling independent of the presence of amino acids and has been shown to reduce B cell competitiveness in the GC 56 (Figure 2). In contrast, expression of mutant alleles of the gene RagC that drive partial but not complete uncoupling of mTORC1 activity from amino acid dependence has been shown to boost GC expansion 68 (Figure 2).…”
Section: Me Taboli C Bal An Ce In Ac Tivated and G Erminal Center Bmentioning
confidence: 99%
“…Other pathways included modulators of metabolism and mitochondria. In mature B cells, the ERK5 signaling pathway, which is indispensable for BAFFinduced mature B cell survival and self-reactivity, was affected (53,54), as well as the mechanistic target of rapamycin (mTOR) and transforming growth factor (TGF)-b signaling pathways (55,56). Together, the large number of affected pathways suggests compound effects of mutant proteomes in the absence of SRPK3.…”
Section: Discussionmentioning
confidence: 99%
“…6 As shown in Fig. 6, the expression of mTOR was seemed to increase in PBM treatment group over 660 nm, but not significantly.…”
Section: The Pbm Effect On Mtor Expression Of Hce-t Corneal Epitheliamentioning
confidence: 91%
“…mTORC2, by comparison, is more specifically activated by growth factor signaling, and facilitates cell survival and cytoskeletal reorganization to promote cell migration and adhesion. 6,23 In addition, the Rho-GTPase family has been known to the target of mTORC2 kinases. 6 Unlike what we expected, the expression of mTORC2 was significantly decreased after PBM treatment at 470 and 530 nm, and not increased by PBM treatment over 660 nm (Fig.…”
Section: Discussionmentioning
confidence: 99%