2024
DOI: 10.1038/s41598-024-58075-x
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Control of breathing by orexinergic signaling in the nucleus tractus solitarii

Yakun Wang,
Tianjiao Deng,
Xue Zhao
et al.

Abstract: Orexin signaling plays a facilitatory role in respiration. Abnormalities in orexin levels correlate with disordered breathing patterns and impaired central respiratory chemoreception. Nucleus tractus solitarii (NTS) neurons expressing the transcription factor Phox2b contribute to the chemoreceptive regulation of respiration. However, the extent to which orexinergic signaling modulates respiratory activity in these Phox2b-expressing NTS neurons remains unclear. In the present study, the injection of orexin A in… Show more

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Cited by 2 publications
(2 citation statements)
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“…The nucleus tractus solitarii (NTS) plays an important role in regulation of numerous physiological processes, such as homeostatic control of breathing ( Fu et al, 2017 , 2019 ; Yu et al, 2022 ; Wang et al, 2024 ), blood pressure ( Jun et al, 2023 ), energy balance ( Cheng et al, 2020 ), inflammation-induced anxiety ( Brunet and Pattyn, 2002 ; Zhao et al, 2024 ), sodium appetite ( Geerling et al, 2006 ; Resch et al, 2017 ) and nausea-associated behaviors ( Zhang et al, 2020 ). These differential processes require to recruit different subpopulation of NTS neurons and the associated distinct neural circuits.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…The nucleus tractus solitarii (NTS) plays an important role in regulation of numerous physiological processes, such as homeostatic control of breathing ( Fu et al, 2017 , 2019 ; Yu et al, 2022 ; Wang et al, 2024 ), blood pressure ( Jun et al, 2023 ), energy balance ( Cheng et al, 2020 ), inflammation-induced anxiety ( Brunet and Pattyn, 2002 ; Zhao et al, 2024 ), sodium appetite ( Geerling et al, 2006 ; Resch et al, 2017 ) and nausea-associated behaviors ( Zhang et al, 2020 ). These differential processes require to recruit different subpopulation of NTS neurons and the associated distinct neural circuits.…”
Section: Introductionmentioning
confidence: 99%
“…Recently, we demonstrate that a subset of Phox2b-expressing NTS (NTS Phox2b ) neurons serves as central respiratory chemoreceptors to maintain ventilatory homeostasis, gaining better understanding of neural control of breathing by this subpopulation. Moreover, activation of both leptin receptor b and orexin 1 receptor-expressing NTS neurons facilitates breathing ( Yu et al, 2022 ; Wang et al, 2024 ), further highlighting molecular identify.…”
Section: Introductionmentioning
confidence: 99%