Control of Cell Survival in Adult Mammalian Neurogenesis

Kuhn, H. Georg

doi:10.1101/cshperspect.a018895

Cited by 34 publications

(31 citation statements)

References 126 publications

(114 reference statements)

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“…One is the mechanistic aspect, which relates to understanding which cellular and molecular substrates allow the subgranular zone of the dentate gyrus to act as a discrete neurogenic niche in which adult neural stem cells can give rise to neurons, whereas other areas cannot support neurogenesis under physiological (nonpathological) conditions. These topics are discussed in depth in the literature (Beckervordersandforth et al 2015;Choe et al 2015;Kuhn 2015). The other side to this question focuses on how neurogenesis might influence hippo-campal function, taking into account the function of the dentate gyrus as a whole, the properties of the network in which newly generated neurons are incorporated, and the function these new neurons might undertake.…”

mentioning

confidence: 99%

Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus

Toni

Schinder

2015

Cold Spring Harb Perspect Biol

151

120

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The adult hippocampus generates functional dentate granule cells (GCs) that release glutamate onto target cells in the hilus and cornus ammonis (CA)3 region, and receive glutamatergic and γ-aminobutyric acid (GABA)ergic inputs that tightly control their spiking activity. The slow and sequential development of their excitatory and inhibitory inputs makes them particularly relevant for information processing. Although they are still immature, new neurons are recruited by afferent activity and display increased excitability, enhanced activity-dependent plasticity of their input and output connections, and a high rate of synaptogenesis. Once fully mature, new GCs show all the hallmarks of neurons generated during development. In this review, we focus on how developing neurons remodel the adult dentate gyrus and discuss key aspects that illustrate the potential of neurogenesis as a mechanism for circuit plasticity and function.

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mentioning

confidence: 99%

Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus

Toni

Schinder

2015

Cold Spring Harb Perspect Biol

151

120

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“…As in development, neurogenesis in these regions is accompanied by substantial cell death . Phagocytosis, by microglia as well as non‐microglial cells, has been experimentally linked with adult neurogenesis (Figure D).…”

Section: Apoptosis Coupled To Replenishment and Homeostatic Tissue Fumentioning

confidence: 95%

“…112,113 As in development, neurogenesis in these regions is accompanied by substantial cell death. [114][115][116] Mice lacking other phagocytic receptors, such as TAM TKO mice, also displayed a defect in neurogenesis in the DG, with around 60% fewer BrdU + DCX + neuronal precursors/neuroblasts than in WT DG. 118 However, crossing of Axl −/− Mertk −/− to Interleukin-6 −/− mice restored BrdU + DCX + neuronal precursors/neuroblasts numbers closer to those of the WT, indicating that a constant low level of inflammation in the TAM KO mice may be what is harmful to neuronal differentiation, rather than an impaired phagocytic process.…”

Section: Central Nervous Systemmentioning

confidence: 99%

Death begets a new beginning

Bosurgi

Hughes

Rothlin

et al. 2017

Immunological Reviews

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Summary Cell death is a perpetual feature of tissue microenvironments; each day under homeostatic conditions, billions of cells die and must be swiftly cleared by phagocytes. However, cell death is not limited to this natural turnover—apoptotic cell death can be induced by infection, inflammation, or severe tissue injury. Phagocytosis of apoptotic cells is thus coupled to specific functions, from the induction of growth factors that can stimulate the replacement of dead cells to the promotion of tissue repair or tissue remodeling in the affected site. In this review, we outline the mechanisms by which phagocytes sense apoptotic cell death and discuss how phagocytosis is integrated with environmental cues to drive appropriate responses.

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“…Elimination of immature neurons by apoptosis takes place both during development and in adulthood 18,24,53 . This is a fast process, as the time from the initiation of apoptosis to its completion usually takes less than 24 hours 54-57 .…”

Section: Eliminated and Surviving Adult-born Jgns Had A Similar Levelmentioning

confidence: 99%

Enhanced endogenous activity predicts elimination of adult-born neurons in the mouse olfactory bulb

Kovalchuk

Mojtahedi

et al. 2020

Preprint

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Adult-born cells, arriving daily into the rodent olfactory bulb, either integrate into the neural circuitry or get eliminated. Whether these two populations differ in their morphological or functional properties remains, however, unclear. Using in vivo two-photon imaging, we monitored longitudinally the dendritic morphogenesis, odor-evoked responsiveness, endogenous Ca2+ signaling and survival/death of adult-born juxtaglomerular neurons (JGNs). We found that JGN maturation is accompanied by a significant reduction in dendritic complexity, with surviving and subsequently eliminated cells showing similar degrees of reduction and dendritic remodeling. Moreover, ∼63% of subsequently eliminated adult-born JGNs acquired odor-responsiveness before death, with amplitudes and time courses of odor-evoked responses similar to those recorded in the surviving cells. We observed, however, a significant long-lasting enhancement of the endogenous Ca2+ signaling in subsequently eliminated JGNs, visible already 6 days before death. These findings identify the ongoing endogenous Ca2+ signaling as a key predictor of the adult-born JGN’s fate.

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Control of Cell Survival in Adult Mammalian Neurogenesis

Cited by 34 publications

References 126 publications

Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus

Maturation and Functional Integration of New Granule Cells into the Adult Hippocampus

Death begets a new beginning

Enhanced endogenous activity predicts elimination of adult-born neurons in the mouse olfactory bulb

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