Control of citrus blue and green molds by Actinomycin X2 and its possible antifungal mechanism

Gao, Liangliang; Liang, Yan; Xiong, Qin; Huang, Meiling; Jiang, Yueming; Zhang, Jun

doi:10.1016/j.pestbp.2023.105718

Cited by 4 publications

(1 citation statement)

References 62 publications

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“…italicum, and P. polonicum. , The ocean covers over 70% of the Earth’s surface and is home to a vast array of marine life, ranging from large animals to tiny microorganisms. These creatures are capable of producing secondary metabolites as chemical defenses against predators.…”

Section: Introductionmentioning

confidence: 99%

Discovery of Antibacterial Compounds against Xanthomonas citri subsp. citri from a Marine Fungus Aspergillus terreus SCSIO 41202 and the Mode of Action

Zhang,

Gao,

Lin

et al. 2024

J. Agric. Food Chem.

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Citrus canker, caused by Xanthomonas citri subsp. citri (Xcc), is a severe citrus disease. Currently, copper-containing pesticides are widely used to manage this disease, posing high risks to the environment and human health. This study reports the discovery of naturally occurring anti-Xcc compounds from a deep-sea fungus, Aspergillus terreus SCSIO 41202, and the possible mode of action. The ethyl acetate extract of A. terreus was subjected to bioassay-guided isolation, resulting in the discovery of eight anti-Xcc compounds (1–8) with minimum inhibitory concentrations (MICs) ranging from 0.078 to 0.625 mg/mL. The chemical structures of these eight metabolites were determined by integrative analysis of various spectroscopic data. Among these compounds, Asperporonin A (1) and Asperporonin B (2) were identified as novel compounds with a very unusual structural skeleton. The electronic circular dichroism was used to determine the absolute configurations of 1 and 2 through quantum chemical calculation. A bioconversion pathway involving pinacol rearrangement was proposed to produce the unusual compounds (1–2). Compound 6 exhibited an excellent anti-Xcc effect with a MIC value of 0.078 mg/mL, which was significantly more potent than the positive control CuSO4 (MIC = 0.3125 mg/mL). Compound 6 inhibited cell growth by disrupting biofilm formation, destroying the cell membrane, and inducing the accumulation of reactive oxygen species. In vivo tests indicated that compound 6 is highly effective in controlling citrus canker disease. These results indicate that compounds 1–8, especially 6, have the potential as lead compounds for the development of new, environmentally friendly, and efficient anti-Xcc pesticides.

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Section: Introductionmentioning

confidence: 99%

Discovery of Antibacterial Compounds against Xanthomonas citri subsp. citri from a Marine Fungus Aspergillus terreus SCSIO 41202 and the Mode of Action

Zhang,

Gao,

Lin

et al. 2024

J. Agric. Food Chem.

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Levulinic acid as a strategy for control of postharvest citrus blue mold by a newly isolated Penicillium italicum

Bazoti,

Camargo,

Bonatto

et al. 2024

J of Chemical Tech & Biotech

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BACKGROUNDLevulinic acid (LA) is a multifunctional compound that is relevant to the economy of bio‐based chemical products. Citrus sinensis, the Valencia variety, is one of the world's most consumed citrus fruit varieties but suffers significant losses due to blue mold infestation. This research evaluated the inhibitory action of unpurified levulinic acid obtained from watermelon residues against the fungus Penicillium italicum, proposing a new use as a fungal inhibitor.RESULTSLA was evaluated in in vitro tests and inhibited the mycelial growth of the fungus. In in vivo experiments with oranges, fungal proliferation in fruits was investigated by applying a crude mixture containing LA (43 mM) and formic acid (FA, 28 mM), comparing with FA alone and negative control (without inhibitory agent). The weight loss and disease incidence results decreased when LA was used as an inhibitory agent, with no negative impacts on fruit quality being observed. Its inhibitory effect was confirmed by determining the activities of the antioxidant enzymes catalase (CAT), ascorbate peroxidase (APX), superoxide dismutase (SOD), and peroxidase (POD), where there was no increase in activities due to inhibition of the fungus before its proliferation in the fruits.CONCLUSIONThis study provides relevant data on the new use of raw LA as an antifungal agent, an effect still unexplored for this compound in recent literature, offering a practical and innovative solution to combat blue mold.This article is protected by copyright. All rights reserved.

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Marine anticancer drugs in modulating miRNAs and antioxidant signaling

Chuang,

Yen,

Tang

et al. 2024

Chemico-Biological Interactions

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Control of citrus blue and green molds by Actinomycin X2 and its possible antifungal mechanism

Cited by 4 publications

References 62 publications

Discovery of Antibacterial Compounds against Xanthomonas citri subsp. citri from a Marine Fungus Aspergillus terreus SCSIO 41202 and the Mode of Action

Discovery of Antibacterial Compounds against Xanthomonas citri subsp. citri from a Marine Fungus Aspergillus terreus SCSIO 41202 and the Mode of Action

Levulinic acid as a strategy for control of postharvest citrus blue mold by a newly isolated Penicillium italicum

Marine anticancer drugs in modulating miRNAs and antioxidant signaling

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