Control of echolocation pulses by neurons of the nucleus ambiguus in the rufous horseshoe bat,Rhinolophus rouxi

Rübsamen, Rudolf; Schweizer, Hermann

doi:10.1007/bf00612041

Cited by 33 publications

(6 citation statements)

References 42 publications

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“…The developmental map for premotor-motor circuitry in fish (this report), as well as for motor neurons in birds (13) and frogs (17), is based on representatives of similar age. Positioning of premotor neurons that participate in vocal patterning in birds (20, 21) and frogs (22), and motor and premotor neurons in mammals (19, 23, 24), including primates (25), is based on adult phenotypes [but see (8) for developmental studies of caudal hindbrain in mammals]. Most laryngeal motor neurons that shape the temporal envelope of mammalian calls originate from caudal nucleus ambiguus (Amb) (23).…”

Section: Figuresmentioning

confidence: 99%

“…Positioning of premotor neurons that participate in vocal patterning in birds (20, 21) and frogs (22), and motor and premotor neurons in mammals (19, 23, 24), including primates (25), is based on adult phenotypes [but see (8) for developmental studies of caudal hindbrain in mammals]. Most laryngeal motor neurons that shape the temporal envelope of mammalian calls originate from caudal nucleus ambiguus (Amb) (23). Abbreviations: Drt, dorsal reticular nucleus; PAm, nucleus parambigualis; Ri, inferior reticular formation; RAb, nucleus retroambiguus; RAm, nucleus retroambigualis; VPP-VPN-VMN, vocal prepacemaker–pacemaker–motor neurons; XMNc, caudal XMN; XIIts, tracheosyringeal division of hypoglossal motor nucleus.…”

Section: Figuresmentioning

confidence: 99%

“…Although comparable developmental studies have not been done for reptiles and mammals, their adult phenotypes indicate a similar pattern for laryngeal motor neurons (Amb) (18, 19). Premotor neurons that pattern vocal-respiratory mechanisms in birds (RAm/PAm) (20, 21), amphibians (Ri) (22), and mammals (23, 24), including nonhuman primates and humans (Drt/RAb) (25), are topographically comparable to the developing prepacemaker-pacemaker nuclei (VPP-VPN) of fish and, like the VPP-VPN (4), are targets of midbrain vocal neurons (24). …”

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confidence: 99%

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Evolutionary Origins for Social Vocalization in a Vertebrate Hindbrain–Spinal Compartment

Bass

Gilland

Baker

2008

Science

196

164

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The macroevolutionary events leading to neural innovations for social communication, such as vocalization, are essentially unexplored. Many fish vocalize during female courtship and territorial defense, as do amphibians, birds, and mammals. Here, we map the neural circuitry for vocalization in larval fish and show that the vocal network develops in a segment-like region across the most caudal hindbrain and rostral spinal cord. Taxonomic analysis demonstrates a highly conserved pattern between fish and all major lineages of vocal tetrapods. We propose that the vocal basis for acoustic communication among vertebrates evolved from an ancestrally shared developmental compartment already present in the early fishes.Although the genetic basis for human speech receives much attention [e.g., (1,2)], the fundamental issue of the ancestral origins of neural networks for vocal signaling is essentially unexplored. Social, context-dependent acoustic communication occurs in most of the major vertebrate lineages, including fishes (Fig. 1A). Teleost fish, the most species-rich of all vertebrate groups (3), have a simple repertoire of vocalizations complemented by vocal and auditory pathways that are organized similarly to those of amphibians, reptiles, birds, and mammals (4). Batrachoidid fish (midshipman and toadfish), in particular, have an expansive vocal-acoustic network, including a rhythmically firing, pacemaker-motor neuron circuit that directly determines the contraction rate of vocal muscles attached to the swim bladder and, in turn, the temporal properties of calls (5,6) ( Fig. 1B and fig. S1; movies S1 to S3). Because batrachoidids also have readily studied larval stages (7), they were chosen to investigate the hypothesis that fish and terrestrial vertebrates share an ancestral origin of their vocal motor networks. Here, we show that the vocal systems of fishes and tetrapods develop very similarly in a segment-like region that forms a transitional compartment between the caudal hindbrain and rostral spinal cord.

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Section: Figuresmentioning

confidence: 99%

Section: Figuresmentioning

confidence: 99%

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confidence: 99%

See 1 more Smart Citation

Evolutionary Origins for Social Vocalization in a Vertebrate Hindbrain–Spinal Compartment

Bass

Gilland

Baker

2008

Science

196

164

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“…Afferents were reported to terminate in the NA originate from the periaqueductal grey (PAG), the cuneiform nuclei, the red nucleus and the frontal cortex (78,79). Efferent projections to the area postrema, the contralateral NA and the lateral reticular formation were found (78–81). Furthermore, connections to the medial parts of the medulla oblongata and the parabrachial nuclei were described as well (78,79).…”

Section: Resultsmentioning

confidence: 99%

“…Efferent projections to the area postrema, the contralateral NA and the lateral reticular formation were found (78–81). Furthermore, connections to the medial parts of the medulla oblongata and the parabrachial nuclei were described as well (78,79). The aforementioned connections are depicted in Figure 2.…”

Section: Resultsmentioning

confidence: 99%

Vagus nerve stimulation for primary headache disorders: An anatomical review to explain a clinical phenomenon

et al. 2019

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Background Non-invasive stimulation of the vagus nerve has been proposed as a new neuromodulation therapy to treat primary headache disorders, as the vagus nerve is hypothesized to modulate the headache pain pathways in the brain. Vagus nerve stimulation can be performed by placing an electrode on the ear to stimulate the tragus nerve, which contains about 1% of the vagus fibers. Non-invasive vagus nerve stimulation (nVNS) conventionally refers to stimulation of the cervical branch of the vagus nerve, which is made up entirely of vagal nerve fibers. While used interchangeably, most of the research to date has been performed with nVNS or an implanted vagus nerve stimulation device. However, the exact mechanism of action of nVNS remains hypothetical and no clear overview of the effectiveness of nVNS in primary headache disorders is available. Methods In the present study, the clinical trials that investigated the effectiveness, tolerability and safety of nVNS in primary headache disorders were systematically reviewed. The second part of this study reviewed the central connections of the vagus nerve. Papers on the clinical use of nVNS and the anatomical investigations were included based on predefined criteria, evaluated, and results were reported in a narrative way. Results The first part of this review shows that nVNS in primary headache disorders is moderately effective, safe and well-tolerated. Regarding the anatomical review, it was reported that fibers from the vagus nerve intertwine with fibers from the trigeminal, facial, glossopharyngeal and hypoglossal nerves, mostly in the trigeminal spinal tract. Second, the four nuclei of the vagus nerve (nuclei of the solitary tract, nucleus ambiguus, spinal nucleus of the trigeminal nerve and dorsal motor nucleus (DMX)) show extensive interconnections. Third, the efferents from the vagal nuclei that receive sensory and visceral input (i.e. nuclei of the solitary tract and spinal nucleus of the trigeminal nerve) mainly course towards the main parts of the neural pain matrix directly or indirectly via other vagal nuclei. Conclusion The moderate effectiveness of nVNS in treating primary headache disorders can possibly be linked to the connections between the trigeminal and vagal systems as described in animals.

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Anatomical basis for audio-vocal integration in echolocating horseshoe bats

Metzner

1996

J. Comp. Neurol.

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Neurophysiological recordings suggest that audio-vocal neurons located in the paralemniscal tegmentum of the midbrain in horseshoe bats provide an interface between the pathways for auditory sensory processing and those for the motor control of vocalization. To verify these physiological results anatomically, the projection pattern of the audio-vocally active area in the paralemniscal tegmentum was investigated by using extracellular tracer injections of wheat germ agglutinin conjugated to horseradish peroxidase. Several nuclei of the lemniscal auditory pathway (dorsal nucleus of the lateral lemniscus, central nucleus of the inferior colliculus, lateral superior olive) as well as the nucleus of the central acoustic tract appear to project to the paralemniscal tegmentum. Other possible sources of afferent projections are a small but distinctly labeled structure within the lateral hypothalamic area, the substantia nigra pars compacta, the deep mesencephalic nucleus, the rostral portion of the inferior colliculus, the deep and intermediate layers of the superior colliculus, and several small areas in the rhombencephalic reticular formation. No direct efferent projection from the audio-vocally active area of the paralemniscal tegmentum to primarily auditory structures was found. Instead, the main targets were structures that are involved in the control of different motor patterns. These targets include the deep and intermediate layers of the superior colliculus and the dorsomedial portion of the facial nucleus, both of which most probably control pinna movements in cats, and the reticular formation medial and caudal to the facial nucleus and rostral to the nucleus ambiguus, which represents an area involved in the control of vocalization. Hence, the anatomical projection pattern suggests that the paralemniscal tegmentum in horseshoe bats serves as a link between the processing of auditory information and the control of vocalization and related motor patterns.

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Control of echolocation pulses by neurons of the nucleus ambiguus in the rufous horseshoe bat,Rhinolophus rouxi

Cited by 33 publications

References 42 publications

Evolutionary Origins for Social Vocalization in a Vertebrate Hindbrain–Spinal Compartment

Evolutionary Origins for Social Vocalization in a Vertebrate Hindbrain–Spinal Compartment

Vagus nerve stimulation for primary headache disorders: An anatomical review to explain a clinical phenomenon

Anatomical basis for audio-vocal integration in echolocating horseshoe bats

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