Control of Experimental Contact Sensitivity

Claman, Henry N.; Miller, Stephen D.; Conlon, Paul; Moorhead, John W.

doi:10.1016/s0065-2776(08)60195-9

Cited by 79 publications

(30 citation statements)

References 143 publications

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“…Potential immunoregulatory mechanisms in con tact sensitivity have been the subject of extensive in vestigation [6,7]. Most attention has focussed on the role of regulatory cells and in particular on that of suppressor T lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

Depression of Lymph Node Cell Proliferation Induced by Oxazolone

Kimber¹,

Pierce²,

Mitchell³

et al. 1987

Int Arch Allergy Immunol

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The influence of topical exposure to two sensitizing chemicals on draining lymph node cell proliferative responses in BALB/c mice has been examined. Conventional contact sensitization with 4-ethoxymethylene-2-phenyloxazol-5-one (oxazolone) has been shown to induce a rapid and systemic suppression of subsequent proliferative responses to topically applied chemical which can be adoptively transferred to recipient mice with immune lymph node cells. In contrast to some previous reports in which such suppression was found to be largely antigen-specific in nature, we report that, at least initially, the inhibition of lymphocyte proliferation induced by skin sensitization is hapten-non-specific. The relevance of this phenomenon to the regulation of contact sensitization is discussed.

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Section: Discussionmentioning

confidence: 99%

Depression of Lymph Node Cell Proliferation Induced by Oxazolone

Kimber¹,

Pierce²,

Mitchell³

et al. 1987

Int Arch Allergy Immunol

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“…The tendency to weaker sensitization effect of PSA compared with PiCl could possibly be explained by a more rapid dilution of the PSA due to its water solubility in the body fluids than of the PiCl. This resulted in less extensive conjugation to body proteins compared with the PiCl which is a further prerequisite for the sensitization by such hap tens [5,20].…”

Section: Discussionmentioning

confidence: 99%

Sensitizing Ability of Derivatives of Picryl Chloride after Exposure of Mice on the Skin and in the Lung

Enander¹,

Ahlstedt²,

Nygren

et al. 1983

Int Arch Allergy Immunol

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In the present study the immunizing efficacy of antigen or hapten administered by the respiratory route and the resulting inflammatory reactions in the lungs after challenge were studied. We compared the induction of delayed hypersensitivity (DH) and the IgG, IgM, IgA, and IgE antibody formation after immunization with three different trinitrobenzene derivatives by the epicutaneous, the intradermal, and the intraperitoneal routes with the intranasal route. Mice sensitized with picryl chloride (PiCl) epicutaneously or intradermally, or with picryl sulfonic acid (PSA) epicutaneously showed strong DH responses. Moderate DH responses were obtained after sensitization with PSA intradermally and with trinitrophenylated human serum albumin (TNP-HSA) intraperitoneally. Intranasal administration of PSA and TNP-HSA also resulted in moderate DH responses. Strong IgG responses were seen in mice sensitized with PiCl and PSA epicutaneously, intradermally, and also intranasally. Administration of TNP-HSA epicutaneously, intradermally, and intraperitoneally also gave high IgG responses, while intranasal administration only induced moderate ones. Considerable IgM responses were seen only in mice sensitized epicutaneously with PSA. Antibody responses of the IgA isotype were only seen after epicutaneous sensitization with PiCl or PSA and intradermally with PiCl. Histological examination of lung tissue from mice sensitized with PiCl epicutaneously or with PSA intranasally and challenged with PSA intranasally revealed some inflammatory cells around bronchioli, capillaries and in the interstitial tissue. Differentiation of mucous cells in the epithelium covering inflammatory cells was also seen, and a slight increase in mast cell numbers around vessels. However, after sensitization with PiCl epicutaneously, TNP-HSA intranasally, and challenge with 2% TNP-HSA intranasally, a weaker inflammation was seen. In conclusion, intranasal administration of PSA or epicutaneous administration of PSA and PiCl gave strong DH and IgG responses. These sensitization regimes also resulted in pronounced inflammatory reactions in the lungs.

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“…These findings raise many questions as to the nature of the I-J products detected on T cells by this and many other laboratories (1)(2)(3)(4)(16)(17)(18).…”

Section: Discussionmentioning

confidence: 74%

“…Several apparently related, but nonidentical, suppressor regulatory pathways consisting of a variety of T-T interactions have been described (1)(2)(3)(4). Our laboratory has concentrated on one of these models of antigen-specific suppression involving the hapten 4-hydroxy-3-nitrophenyl acetyl (NP).…”

mentioning

confidence: 99%

The role of I-J and Igh determinants on F1-derived suppressor factor in controlling restriction specificity.

Minami

Aoki

Honji

et al. 1983

The Journal of Experimental Medicine

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In the 4-hydroxy-3-nitrophenyl acetyl (NP) contact sensitivity system, the activity of third-order suppressor cells and their factors is restricted by H-2(I-J) and Igh linked genes. The present report analyzes the specificity of NP-specific Ts3 cells and factors derived from H-2 and Igh heterozygous (B6 X C3H)F1 mice. Two approaches were used. First, heterogeneous populations of F1 Ts3 cells were activated in vitro and then assayed in Ts3-depleted recipients which carried different combinations of H-2 and Igh alleles. The second approach was to hybridize the Ts3 cells and analyze the specificity of the F1-derived TsF3. The combined data demonstrated four functionally distinct populations of Ts3 cells. The activity of each population was restricted by a particular combination of H-2 and Igh haplotypes. Thus, Ts3 cells derived from F1 donors can demonstrate an apparent scrambling of H-2 and Igh restriction specificities. There was functional allelic exclusion of the H-2(I-J) and Igh determinants expressed on (B6 X C3H)F1 hybridoma-derived TsF3. Thus, TsF3 from each cloned hybridoma line expressed only one set of I-J and Igh determinants. Furthermore, there was a complete correlation between the I-J and Igh linked determinants expressed on TsF3 and the restriction specificity. In view of the recent findings on the molecular biology of the I-J region, an alternative interpretation of the role of I-J determinants on suppressor cells and factors is offered.

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Control of Experimental Contact Sensitivity

Cited by 79 publications

References 143 publications

Depression of Lymph Node Cell Proliferation Induced by Oxazolone

Depression of Lymph Node Cell Proliferation Induced by Oxazolone

Sensitizing Ability of Derivatives of Picryl Chloride after Exposure of Mice on the Skin and in the Lung

The role of I-J and Igh determinants on F1-derived suppressor factor in controlling restriction specificity.

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