Control of Exposure to Mite Allergen and Allergen-Impermeable Bed Covers for Adults with Asthma

Woodcock, Ashley; Forster, L; Matthews, Edward; Martín, J F; Letley, Louise; Vickers, Martin; Britton, John; Strachan, David P.; Howarth, Peter H.; Altmann, Daniel R.; Frost, Chris; Čustović, Adnan

doi:10.1056/nejmoa023175

Cited by 266 publications

(175 citation statements)

References 27 publications

Supporting

Mentioning

169

Contrasting

Unclassified

Order By: Relevance

“…For example, the use of allergen-barrier mattress pads and pillow covers to reduce exposure to dust mites has shown inconsistent results. [22][23][24][25][26] In addition, reducing cockroach allergen in urban homes is challenging and in some studies has produced no apparent clinical benefit. 22,27 However, a recent intervention aimed at reducing exposure to multiple indoor allergens and ETS has produced a significant and sustained decrease in asthma symptoms.…”

Section: Resultsmentioning

confidence: 99%

Indoor Environmental Exposures Among Children With Asthma Seen in an Urban Emergency Department

et al. 2006

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Indoor Environmental Exposures Among Children With Asthma Seen in an Urban Emergency Department

et al. 2006

View full text Add to dashboard Cite

show abstract

“…The studies might explain why avoidance of a single exposure has only marginal or no effects when other exposures are still existing, as might have been the case in other prevention studies [18,35]. In tertiary prevention of asthma intervention studies [46], focusing on a reduction of multiple environmental exposures has shown promising results, whereas the results of clinical trials targeting only one allergen were disappointing [47,48]. These studies and the current findings are a plea in favour of pursuing a multifaceted approach with respect to the prevention of asthma.…”

Section: Discussionmentioning

confidence: 99%

The PREVASC study: the clinical effect of a multifaceted educational intervention to prevent childhood asthma

Schönberger

Dompeling²,

Knottnerus³

et al. 2005

Eur Respir J

View full text Add to dashboard Cite

As asthma is the most common chronic disease in childhood, much attention is directed towards primary prevention. Here, the clinical effectiveness of a multifaceted educational prevention was studied.A total of 476 high-risk children were recruited during the prenatal period by general practitioners and randomised to either: 1) a control group, receiving usual care; or 2) an intervention group in which families received instruction from nurses on how to reduce exposure of newborns to mite, pet and food allergens, and passive smoking.A total of 443 infants were followed-up for 2 yrs. At 2 yrs of age, the intervention group (n5222) had less asthma-like symptoms, including wheezing, shortness of breath and night-time cough, than the control group (n5221). No significant differences in total and specific immunoglobulin E were found between the groups. During the first 2 yrs of life, the incidence of asthma-like symptoms was similar in both groups; however, subanalysis revealed a significant reduction in the female, but not in the male, intervention group.In conclusion, the intervention used in this study was not effective in reducing asthma-like symptoms in high-risk children during the first 2 yrs of life, although it was modestly effective at 2 yrs. Follow-up is necessary to confirm whether the intervention can actually prevent the development of asthma.

show abstract

“…Although asthma [26] and rhinitis [27] guidelines are underpinned by aeroallergen avoidance [28] there is, as yet, insufficient evidence of the feasibility, effectiveness and cost-effectiveness of avoidance C o p y r ig h t G e n e r a l P r a c t ic e A ir w a y s G r o u p R e p r o d u c t io n p r o h ib it e d measures [29][30][31][32] in order to convince those working in primary care that routine performance of objective diagnostic tests which underpin allergen avoidance advice (skin prick tests/specificIgE tests) is worthwhile. For the majority, identification of a specific allergic trigger is not necessary as long as symptoms respond to pharmacotherapy; in cases that do not, identification and avoidance of allergens may offer some benefit.…”

Section: Management Of Allergymentioning

confidence: 99%

Management of allergic problems in primary care: time for a rethink?

Morris

Sheikh

Walker³

2005

Primary Care Respiratory Journal

View full text Add to dashboard Cite

SummaryAllergic diseases affect 20-30% of the UK population and when severe are associated with considerable morbidity and occasional mortality. Initiatives to improve allergy services in the UK have been led by consultant allergists and have focussed on increasing the number of hospital training posts to improve access to specialist services. A high profile campaign to raise awareness of the lack of allergy services has so far failed to generate further training numbers for allergy as a single specialty. Although the campaign to improve tertiary allergy services continues, most mild or moderate allergy symptoms (e.g. hayfever, allergic asthma, urticaria and some food allergy problems), can be managed successfully in primary care with appropriate interest and training. Despite the high and increasing numbers of patients with allergy and the ease with which the majority of symptoms can be controlled, many doctors in primary care are reluctant to take a more proactive approach to managing allergic conditions. This appears to be due to concerns about overburdening an already busy service, but may also be due to recommendations from allergy specialists which have implied that high quality allergy care is not possible without identification of specific allergic triggers using skin prick tests or blood tests. In reality, symptoms can usually be controlled using pharmacotherapy, although a working knowledge of the appropriate guidelines is helpful. In this paper,we propose minimum levels of knowledge for all practitioners in order to raise the standards of primary care allergy management, and provide recommendations for * Corresponding author. training for those wishing to manage successfully more difficult allergy cases and allergy diagnosis.

show abstract

Control of Exposure to Mite Allergen and Allergen-Impermeable Bed Covers for Adults with Asthma

Cited by 266 publications

References 27 publications

Indoor Environmental Exposures Among Children With Asthma Seen in an Urban Emergency Department

Indoor Environmental Exposures Among Children With Asthma Seen in an Urban Emergency Department

The PREVASC study: the clinical effect of a multifaceted educational intervention to prevent childhood asthma

Management of allergic problems in primary care: time for a rethink?

Contact Info

Product

Resources

About