Control of female gamete formation by a small RNA pathway in Arabidopsis

Olmedo-Monfil, Vianey; Durán-Figueroa, Noé; Arteaga-Vázquez, Mario; Demesa-Arévalo, Edgar; Autran, Daphné; Grimanelli, Daniel; Slotkin, R. Keith; Martienssen, Robert A.; Vielle‐Calzada, Jean‐Philippe

doi:10.1038/nature08828

Cited by 523 publications

(615 citation statements)

References 33 publications

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“…It was shown that gamete formation requires AGO9, which controls female gamete formation in a non-cell autonomous manner (Olmedo-Monfil et al, 2010). In grafted Arabidopsis and Nicotiana the systemic silencing penetrated male sporogenic tissues suggesting that plants harbor an endogenous longdistance small RNA transport pathway facilitating siRNA signalling into meiotically active cells.…”

Section: Flower/seed Concerning Silencing Spreadingmentioning

confidence: 99%

“…AGO9 is involved in RNA-directed DNA methylation and is highly enriched in the germline (Oliver et al, 2014) where it controls female gamete formation by repressing the specification of germ cell fate through epigenetic reprogramming in companion somatic cells (Olmedo-Monfil et al, 2010). Zea mays AGO2 homolog (originally designated ZmAGO104) is also specifically expressed in the somatic cells surrounding future gametes but it had an opposing function -it suppresses the somatic cell fate in germ cells (Singh et al, 2011).…”

Section: Ago8 -Seems To Be a Pseudogene In A Thaliana (Zhang Et Almentioning

confidence: 99%

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Literature review of baseline information to support the risk assessment of RNAi‐based GM plants

Pačes

Nič²,

Novotný³

et al. 2017

EFS3

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This report is the outcome of an EFSA procurement aiming at investigating and summarising the state of knowledge on (I) the mode-of-action of dsRNA and miRNA pathways, (II) the potential for nontarget gene regulation by dsRNA-derived siRNAs or miRNAs, (III) the determination of siRNA pools in plant tissues and the importance of individual siRNAs for silencing. The report is based on a comprehensive and systematic literature search, starting with the identification and retrieval of~190,000 publications related to the research area and further filtered down with keywords to produce focused collections used for subsequent screening of titles and abstracts. The report is comprised of an (I) Introduction to the field of small RNAs, (II) a Data and Methodologies section containing strategies used for literature search and study selection, and (III) the Results of the literature review organized according to the three main procurement tasks. The outcome of the first task reviews dsRNA and miRNA pathways in mammals (including humans), birds, fish, arthropods, annelids, molluscs, nematodes, and plants. Eight taxon-dedicated chapters are based on~1,400 cumulative references chosen from~10,000 inspected titles and abstracts. We review conserved and divergent aspects of small RNA pathways and dsRNA responses in animals and plants including structure and function of key proteins as well as four basic mechanisms: genome-encoded posttranscriptional regulations (miRNA), degradation of RNAs by short interfering RNA pools generated from long dsRNA (RNAi), transcriptional silencing, and sequence-independent responses to dsRNA. The outcome of the second task focuses on base pairing between small RNAs and their target RNAs and predictability of biological effects of small RNAs in animals and plants. The outcome of the last task reviews methodology, siRNA pools, and movement of small RNAs in plants. Potential transfer of small RNAs between species and circulating miRNAs in mammals is described in the final chapter.

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Section: Flower/seed Concerning Silencing Spreadingmentioning

confidence: 99%

Section: Ago8 -Seems To Be a Pseudogene In A Thaliana (Zhang Et Almentioning

confidence: 99%

Literature review of baseline information to support the risk assessment of RNAi‐based GM plants

Pačes

Nič²,

Novotný³

et al. 2017

EFS3

View full text Add to dashboard Cite

show abstract

“…AGO9 is expressed in cytoplasmic foci of somatic companion cells. AGO9 preferentially interacts with 24-nucleotide siRNAs derived from TEs and silences TEs in female gamete and their accessory cells likely in a non-cell-autonomous manner, thereby repressing germ cell fate in somatic cells (Olmedo-Monfil et al, 2010). In maize, the AGO9 homolog (named AGO104) is specifically expressed in the somatic cells around the precursors of the gametic cells but acts to repress somatic fate in germ cells (Singh et al, 2011).…”

Section: Ago2/3/7 Cladementioning

confidence: 99%

RNAi in Plants: An Argonaute-Centered View

2016

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Argonaute (AGO) family proteins are effectors of RNAi in eukaryotes. AGOs bind small RNAs and use them as guides to silence target genes or transposable elements at the transcriptional or posttranscriptional level. Eukaryotic AGO proteins share common structural and biochemical properties and function through conserved core mechanisms in RNAi pathways, yet plant AGOs have evolved specialized and diversified functions. This Review covers the general features of AGO proteins and highlights recent progress toward our understanding of the mechanisms and functions of plant AGOs.

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“…Mutations in AGO9 lead to the differentiation of multiple female gamete precursors that are able to initiate gametogenesis and give rise to independent female gametophytes in the ovule, in a pattern reminiscent of aposporous apomixis (Olmedo-Monfil et al 2010). The AGO9 protein is not expressed in the gamete lineage; instead, it is expressed in somatic companion cells.…”

Section: Epigenetic Control Of Cell Specification In the Arabidopsismentioning

confidence: 99%

Reproductive Versatility and the Epigenetic Control of Female Gametogenesis

Vielle‐Calzada

Hernandez-Lagana

Rodríguez-Leal

et al. 2012

Cold Spring Harbor Symposia on Quantitative Biology

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Each year, plants and animals perform the task of repopulating the planet through patterns of courtship and mating that have a unifying and compelling logic: the production of offspring. Although life of nearly all organisms is organized around sex and breeding, Darwinian thinking focused more on the struggle for existence than on evolutionary significance of this frantic race to reproduce. In Darwin's own words, "We do not know the final cause of sexuality; why new beings should be produced by the union of the two sexual elements. The whole subject is hidden in darkness. . ." (Darwin 1862). In plants, a major consequence of this search for survival is the evolution of a multitude of reproductive alternatives that have intrigued botanists, geneticists, and evolutionary biologists for more than 100 years. Because sexually derived genetic diversity is interpreted as essential for adaptation, it is often thought that sex is necessary for the perpetuation of a species; however, many organismsincluding several hundred families of flowering plants-are going efficiently about propagating their kind without bothering with meiosis and mating. Whereas many plants can undergo vegetative propagation, through the production of stolons, bulbs, or rhizomes, for example, many others have developed methods to produce an embryo from a single cell whose nucleus is not formed by the fusion of two gametes, offering a direct developmental and evolutionary challenge to sexual reproduction. Recent evidence suggests that epigenetic mechanisms that control transcriptional silencing of DNA repetitive elements and heterochromatin are crucial for the acquisition of cell identity in the ovule, opening the possibility that the developmental distinction between sexual development and apomixis might have evolved as an adaptive response to evolutionary forces that modulate structural variation and reproductive versatility in flowering plants.The emergence of all plants is derived from a common ancestor that endosymbiotically acquired a photosynthetic bacterium capable of transforming light into energy, an evolutionary event that changed the surface of the planet by progressively transforming an environment dominated by cyanobacteria (blue-green bacteria) into a habitat predominantly occupied by photosynthetic multicellular organisms. Although fossilized spores suggest that land plants appeared more than 450 million years ago, the establishment of their life cycle through the alternation of haploid and diploid generations remains an unsolved mystery. In contrast to green algae and mosses, in which the gametophytic (haploid) phase is free-living and temporally dominant, flowering plants have a reduced and ephemeral gametophyte that forms male and female gametes and is necessary to ensure sexual reproduction.Plants have evolved a characteristic life strategy with alternating diploid and haploid phases (or generations), continuous postembryonic development that derives in the formation of aerial and underground meristems, and the absence of a germli...

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Control of female gamete formation by a small RNA pathway in Arabidopsis

Cited by 523 publications

References 33 publications

Literature review of baseline information to support the risk assessment of RNAi‐based GM plants

Literature review of baseline information to support the risk assessment of RNAi‐based GM plants

RNAi in Plants: An Argonaute-Centered View

Reproductive Versatility and the Epigenetic Control of Female Gametogenesis

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