Control of Fertilization by Immunization With Peptide Fragments of Sperm Specific LDH-C4

Experimental immunological infertility effect of anti-GAPDH-2 antibodies on the fertility of female mice

“…Sperm-specific antigens are potential candidates in the development of immunocontraceptives. Notable factors include the fertilization antigen-1 (19), , PH-30 (21), sperm protein (SP-10) (22), SP-17 (23), testis-specific antigen-1 (24), contraceptive vaccinogen (25), protein A-kinase anchoring protein (26), lactate dehydrogenase C4 (27)(28)(29), sperm-associated antigen 9 (30), epididymal protein inhibitor (31), YLP12 (32), and the sperm fusion-related antigen, Izumo (33)(34)(35). We proposed that GAPDH-2 could be considered as a potential sperm antigen to be further evaluated as an infertile immunogen.…”