2024
DOI: 10.1073/pnas.2407744121
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Control of G protein–coupled receptor function via membrane-interacting intrinsically disordered C-terminal domains

Chiara D. Mancinelli,
Dagan C. Marx,
Alberto J. Gonzalez-Hernandez
et al.

Abstract: G protein–coupled receptors (GPCRs) control intracellular signaling cascades via agonist-dependent coupling to intracellular transducers including heterotrimeric G proteins, GPCR kinases (GRKs), and arrestins. In addition to their critical interactions with the transmembrane core of active GPCRs, all three classes of transducers have also been reported to interact with receptor C-terminal domains (CTDs). An underexplored aspect of GPCR CTDs is their possible role as lipid sensors given their proximity to the m… Show more

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