Control of Hemoglobin Synthesis in Fetal Erythroid Cells by L‐Thyroxine

Abstract

Fetal mouse liver cells were incubated in the presence of L-thyroxine, Globin synthesis by cells from the 13th to 15th days of gestation was stimulated by the presence of the hormone. Although protein synthesis by cells from the 17th day of gestation was stimulated, the protein was not identified as globin. A tentative conclusion was drawn that fetal erythroid tissue may be preferentially stimulated by thyroid hormone.

Characterization of the anaemia associated with Graves’ disease

“…Thus, the calorigenic and erythropoietic actions of thyroid hormone may be uncoupled. T4 promotes heme synthesis and degradation in the liver 15–18 . It shifts the Hgb dissociation curve to the right 2 facilitating tissue oxygen delivery, suggesting that a secondary elevation of EPO may not represent the sole compensatory mechanism.…”

“…T4 promotes heme synthesis and degradation in the liver. [15][16][17][18] It shifts the Hgb dissociation curve to the right 2 facilitating tissue oxygen delivery, suggesting that a secondary elevation of EPO may not represent the sole compensatory mechanism. In our study, patients with GD anaemia presented with EPO levels within the normal range (Table 2).…”