Control of IgE and selective TH1 and TH2 cytokines by PG102 isolated from Actinidia arguta

Fatty Acid Components of Hardy Kiwifruit (Actinidia arguta) as IL-4 Production Inhibitor

“…Among the various treatments, herbal treatments are often used for dermatological conditions such as atopic dermatitis. AA has been demonstrated to possess both in vivo and in vitro anti-infl ammatory effects (Park et al, 2005). Although AA has high inhibitory effects on allergic diseases, the active compounds causing these effects have not been identifi ed.…”

“…In Korean traditional medicine, it has been known to have effects on allergic disorders, diuresis, diabetes mellitus, osteoporosis, cardiopathy, and gastroenteric trouble. Recently, it was reported that the PG102 fraction from AA controls IgE and selective T H 1 and T H 2 cytokines (Park et al, 2005). And DA9102, isolated from AA, suppressed the mRNA expression of T H 2 cytokines including IL-4 and IL-10 in the Mg-defi ciency induced dermatitis model of hairless rats (Choi et al, 2007).…”

Natural Products and Dermatological Hypersensitivity Diseases

“…Compound PG102 and isolated from this fruit by Park et al in 2005 and found to have oral immune modulating effects in mice (Park et al, 2005). A follow up study conducted to determine the effect on the NC/Nga mice model (Park et al, 2007), found that after 9 weeks, PG102 showed statistically significant beneficial effect on AD symptoms and scratching behavior, while noted immunomolecular effects showed a decrease in IgE, IgG, IL4 while IL12 was increased.…”

Anti-Diabetic Effects of Actinidia arguta Polyphenols on Rats and KK-Ay Mice

“…There have been few reports on the function of A. arguta, except for the antiallergic and anti-inflammatory effects of A. arguta extract PG102 Park et al, 2005) and for the proliferation promoting effects of (+) catechin and (−) epicatechin from the stems of A. arguta on bone marrow cells (Takano et al, 2003). In determining the functionality of A. arguta, we focused on polyphenols and investigated whether they could inhibit glucose absorption and/or the elevation of postprandial blood glucose levels.…”