Control of immunopathology during chikungunya virus infection

Petitdemange, Caroline; Wauquier, Nadia; Vieillard, Vincent

doi:10.1016/j.jaci.2015.01.039

Cited by 61 publications

(57 citation statements)

References 86 publications

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“…CHIKV has been reported in many countries in Asia, America, and Africa after an epidemiologic silent period as a neglected tropical disease (2). The reemergence of CHIKV as an urban epidemic was described in Kinshasa, Democratic Republic of the Congo, in 2000 (15).…”

Section: Discussionmentioning

confidence: 99%

“…The Pan American Health Organization recorded 776,000 cases and 152 deaths attributed to CHIKV infection in 33 countries in 2014 (http://www.paho.org/chikungunya). CHIKV infection has been identified in nearly 80 countries across 5 continents and caused more than 6 million confirmed cases (2). While CHIKV imported cases into Northern Italy were very low between 2011 and 2013, the number of imported cases has increased significantly since 2014 (16).…”

Section: Discussionmentioning

confidence: 99%

“…The CHIKV is transmitted primarily by Aedes aegypti and Aedes albopictus mosquitoes (1). CHIKV infection led to more than 6 million confirmed cases worldwide (2). CHIKV has a wide geographic distribution including North and South America, Europe, Asia, the Pacific Islands, and Africa since the virus was first described in Tanzania in 1952 (3,4).…”

Section: Introductionmentioning

confidence: 99%

“…Fever (over 39 °C), arthritis, arthralgia, rash, and lymphopenia are more significant in a CHIKV infection. While hemoconcentration does not occur in CHIKV infection, it is present in 70%-100% of dengue virus-infected patients (2). Diagnosis of CHIKV infection is based on molecular detection of a viral genome and/or serological detection of virus-specific antibodies.…”

Section: Introductionmentioning

confidence: 99%

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A study of the chikungunya virus in humans in Turkey

Atalay¹,

Kaygusuz²,

Azkur³

2017

Turk J Med Sci

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IntroductionThe chikungunya virus (CHIKV) is a single-stranded, positive sense RNA virus that is a member of the genus Alphavirus of the family Togaviridae. The CHIKV is transmitted primarily by Aedes aegypti and Aedes albopictus mosquitoes (1). CHIKV infection led to more than 6 million confirmed cases worldwide (2). CHIKV has a wide geographic distribution including North and South America, Europe, Asia, the Pacific Islands, and Africa since the virus was first described in Tanzania in 1952 (3,4). A female patient who came from India to Turkey with symptoms of fever, arthralgia, and rashes was the first case of laboratory-confirmed CHIKV infection in Turkey (5). Clinical symptoms of CHIKV infection include high fever, fatigue, backache, headache, and polyarthralgia. Polyarthralgia is the most characteristic and common symptom of infection and also the origin of the name of the disease "chikungunya, " a local term in the Makonde language that means "disease that bends up the joints". In addition to these clinical manifestations, tenosynovitis, swollen joints, macular or maculopapular skin rashes, myalgia, nausea, vomiting, and diarrhea can be observed in CHIKV-infected patients (3,6). Differential diagnosis of CHIKV infection from dengue virus infection could be based on clinical manifestations and laboratory features. Fever (over 39 °C), arthritis, arthralgia, rash, and lymphopenia are more significant in a CHIKV infection. While hemoconcentration does not occur in CHIKV infection, it is present in 70%-100% of dengue virus-infected patients (2). Diagnosis of CHIKV infection is based on molecular detection of a viral genome and/or serological detection of virus-specific antibodies. RT-PCR and real-time RT-PCR (7-9) can be used for molecular detection while serological diagnostic tests include ELISA, immunofluorescence assay, and rapid immunochromatographic test (10-13). The aim of this study was to screen for possible exposure to CHIKV infections in humans using ELISA and IIFT in the city of Kırıkkale, which is located in the central Anatolia region of Turkey. Materials and methods SamplesBlood samples were taken from 500 healthy, randomly selected volunteer blood donors who live in Kırıkkale (39°50ʹN; 33°31ʹE; altitude 700 m) through July-November Background/aim: The chikungunya virus (CHIKV) is a mosquito-borne disease and has recently been causing explosive outbreaks. The CHIKV has spread throughout all continents. Although the first chikungunya case imported from India to Turkey was reported in 2012, there is no detailed epidemiologic study in Turkey yet. The aim of this study was to investigate the seroprevalence of the CHIKV in Turkey.Materials and methods: ELISA was used to screen 500 random serum samples of healthy people collected from Kırıkkale, which is located in central Anatolia in Turkey. The results were verified by indirect immunofluorescence test (IIFT). Results:The results showed that 0.4% samples were positive for CHIKV. In the verification study with IIFT, CHIKV IgG type antibodies were defi...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A study of the chikungunya virus in humans in Turkey

Atalay¹,

Kaygusuz²,

Azkur³

2017

Turk J Med Sci

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“…The current understanding of protective immune responses to CHIKV infection has been derived from animal models as well as limited human data following natural infection [11]. The humoral immune response seems to play a more important role in controlling CHIKV infection than cell mediated immunity (CMI).…”

Section: Biological Feasibility For Vaccine Developmentmentioning

confidence: 99%

Status of research and development of vaccines for chikungunya

Smalley

Erasmus

Chesson

et al. 2016

Vaccine

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Chikungunya virus (CHIKV) is an arthritogenic alphavirus that during the last decade has significantly expanded its geographical range and caused large outbreaks of human disease around the world. Although mortality rates associated with CHIKV outbreaks are low, acute and chronic illnesses caused by CHIKV represent a significant burden of disease largely affecting low and middle income countries. This report summarizes the current status of vaccine development for CHIKV.

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Immunological impact of cytokines on the chikungunya virus pathophysiology: A literature narrative review

Nunes

Sousa

Smith

et al. 2023

Reviews in Medical Virology

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The chikungunya virus (CHIKV) is a member of the genus Alphavirus, family Togaviridae. CHIKV causes an acute systemic febrile condition, accompanied by severe polyarthralgia, intense muscle pain, and maculopapular exanthema, which may still occur in many patients. In rare cases, unusual symptoms may occur, eventually worsening the condition and resulting in a fatal outcome. It is a single‐stranded, non‐segmented RNA virus with a genome of approximately 11,805 nucleotides that organises a genetic and molecular chain that encodes non‐structural proteins (nsP1, nsP2, nsP3, nsP4) and structural proteins (E3, E2, 6K, and E1). The fundamental role of immune response in the evolution of the disease is known. Understanding the role of immune response in the pathogenesis of CHIKV infection is challenging. In this context, innate and adaptive immune responses establish a connective interface that induces the production of various mediators that modulate the strategy of inhibiting viral replication. However, the immune escape articulated by the virus indicates that the action of pro‐and anti‐inflammatory cytokines contributes to the worsening of the disease and potentiates tissue damage with joint involvement. In this review, we discuss the role of the primary pro‐and anti‐inflammatory cytokines in the immunopathological processes of chikungunya fever.

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Control of immunopathology during chikungunya virus infection

Cited by 61 publications

References 86 publications

A study of the chikungunya virus in humans in Turkey

A study of the chikungunya virus in humans in Turkey

Status of research and development of vaccines for chikungunya

Immunological impact of cytokines on the chikungunya virus pathophysiology: A literature narrative review

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