Control of intraoperative hemorrhage in gynecology with the use of fibrin glue

Thermal Injury Resulting from Application of a Granular Mineral Hemostatic Agent

“…7 Biological agents used for topical hemostasis have the advantage of absorbability and low wound toxicity, but the potential disadvantage of invoking an allergic reaction. 8 Among the biologics that have been used for hemostasis are microfibrillar collagen, 9 collagen sponges, 10 gelatin, 11 cellulose, 12 fibrin glue, 13 and thrombin spray. 14 While effective in a controlled surgical setting, few of these agents have shown the robust activity which would be required to control massive hemorrhage in a remote setting.…”

Extraperitoneal Pelvic Packing: A Salvage Procedure to Control Massive Traumatic Pelvic Hemorrhage

“…3,4 Vascular injuries in association with pelvic trauma may be difficult to address because of the abundant collateral blood supply of the pelvis, and several different techniques of attaining bleeding control have been described, such as ligation of the iliac artery or vein, application of local hemostatic therapies, attachment of sterile thumbtacks to the sacrum, cautery, and bone wax. [5][6][7][8] None of these techniques have, however, proven successful because of anatomic reasons. 9 In the past years emergent angiographic embolization has been advocated in the control of life-threatening pelvic hemorrhage.…”

Use of Monsel solution to treat obstetrical hemorrhage: a review and comparison to other topical hemostatic agents

“…Tisseel™ (Baxter) is a proprietary spray sealant composed of human fibrin and thrombin. Tisseel™ has been used successfully for hemostasis of complex obstetric lacerations [69], postpartum hemorrhage from obstetric trauma [70], and life-threatening gynecologic hemorrhage as early as 1989 [71]. Notably, use with oxidized cellulose matrix can reduce efficacy.…”