Control of Lipæmia in Children With Diabetes Mellitus

Salt, H.B.; Wolff, O. H.; Nestadt, A.; Lloyd, J. K.

doi:10.1016/s0140-6736(60)92897-x

Cited by 26 publications

(2 citation statements)

References 10 publications

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“…This fact may have big impact on the evolution of the disease, because it is known since 50 years ago that increased plasma NEFA increase insulin resistance (Randle cycle) and this parameter is a predictor of conversion from normal glucose tolerance to impaired glucose tolerance . The control of lipemia has been a key issue in the management of the disease since the mid‐20th century , and it is still a matter of research, with new metabolomic (lipidomic) strategies helping in deciphering the variations in every lipid fraction.…”

Section: Discussionmentioning

confidence: 99%

Plasma and urine metabolic fingerprinting of type 1 diabetic children

et al. 2013

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Type 1 diabetes mellitus is one of the most common chronic disorders of childhood. The metabolic control is lost due to the lack of insulin, which is the main treatment for the disease. Nevertheless, long-term complications appear even under good glycemic control. Metabolomics, an emerging strategy, can help in diagnosis, prognosis, and monitoring of metabolic disorders. The objective of the present study was to investigate the alterations in plasma (by LC-MS) and urine (CE-MS) of type 1 diabetic children that were under insulin treatment and good glycemic control. Even without remarkable biochemical differences between the two groups (diabetic and control) except for glucose level and glycosilated hemoglobin, metabolomic tools were able to capture subtle metabolic differences. The main changes in plasma were associated to lipidic metabolism (nonesterified fatty acids, lysophospholipids, and other derivatives of fatty acids), and some markers of the differential activity of the gut microflora were also found (bile acids, p-cresol sulfate). In urine, changes associated to protein and amino acid metabolism were found (amino acids, their metabolites and derivatives), and among them one advanced glycation end product (carboxyethylarginine) and one early glycation end product (fructosamine) were excreted in higher proportion in the diabetic group.

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Section: Discussionmentioning

confidence: 99%

Plasma and urine metabolic fingerprinting of type 1 diabetic children

et al. 2013

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“…Thus the onset of vascular complications in diabetic children might be delayed by giving optimum insulin dosage to maintain normal serum lipid levels. However, since a diet rich in polyunsaturated fat also lowers serum lipid levels, the use of such a diet could serve as an additional controlling measure (5). For this reason, a diet rich in corn oil and corn oil products (6) has been prescribed to a group of diabetic children at Birmingham Children's Hospital since the time of diagnosis 4-7 yr ago.…”

Section: Introductionmentioning

confidence: 99%