Control of locally advanced extremity soft tissue sarcomas by function-saving resection and brachytherapy

Shiu, Man H.; Turnbull, A. D.; Nori, Dattatreyudu; Hajdu, Steven I.; Hilaris, B.S.

doi:10.1002/1097-0142(19840315)53:6<1385::aid-cncr2820530628>3.0.co;2-z

Cited by 111 publications

(22 citation statements)

References 14 publications

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“…[49] 1987 Radiotherapy Shiu et al . [50] 1984 Radiotherapy O'Sullivan et al . [51] 2002 Radiotherapy…”

Section: Thighmentioning

confidence: 99%

“…The concern with radiation therapy is the complications it causes with wound healing. Reported complications have ranged from 33%-44% in the past, with severe morbidity in 22%-27% of patients [48][49][50] . Abramson et al [5] however only reported a 12.5% wound complication rate, including a patient who developed radiation necrosis and required a second free tissue transfer months after his initial treatment.…”

Section: Neoadjuvant and Adjuvant Therapymentioning

confidence: 99%

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Complex reconstruction of the lower extremity following sarcoma resection: a literature review

Azadgoli¹,

Carre²,

Perrault³

et al. 2018

PAR

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While amputation was traditionally the only option available for patients with sarcomas of the extremities, chemotherapy, radiation, and advances in microsurgical technique have allowed many patients to undergo limb-salvaging procedures. Given the low incidence and heterogeneity of these tumors, there is currently no standard treatment algorithm for limb reconstruction after large sarcoma resection. Thus, we systematically reviewed the various types of free tissue transfer used for the reconstruction of lower limbs after sarcoma resection. Techniques were described based on anatomic location. This literature review supports free tissue transfer as a safe and acceptable modality for reconstruction after sarcoma resection of the lower limb. It allows for the application of healthy vascularized tissue to the defect while also providing freedom of flap positioning. Flap choice is dependent on tumor and defect size, tissue type and function, as well as donor site availability.

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“…[49] 1987 Radiotherapy Shiu et al . [50] 1984 Radiotherapy O'Sullivan et al . [51] 2002 Radiotherapy…”

Section: Thighmentioning

confidence: 99%

Section: Neoadjuvant and Adjuvant Therapymentioning

confidence: 99%

Complex reconstruction of the lower extremity following sarcoma resection: a literature review

Azadgoli¹,

Carre²,

Perrault³

et al. 2018

PAR

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“…335 From the 1970s, following the original concepts introduced in the 1960s, 6 adjuvant external-beam radiation, brachytherapy, and chemotherapy in combination with limited surgery were identified as effective modalities in terms of survival for patients with bone and soft tissue sarcomas. 272,288,329,336 In breast carcinomas, combined radiation and chemotherapy had the lowest local recurrence and best overall survival rates compared with either therapy alone. 337 After it was confirmed that operable breast carcinoma treated with radiation and chemotherapy reduced local failure significantly better than either modality alone, the combined modality became standard therapy.…”

Section: Radiation Therapymentioning

confidence: 99%

A note from history: Landmarks in history of cancer, part 7

Hajdu

Vadmal

Tang

2015

Cancer

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In the 2 and half decades reviewed , research established that chromosomal translocation, deletion, and DNA amplification are prerequisites to cancerogenesis and that oncogenes, tumor-suppressor genes, growth factors, and cytokines play crucial roles in the pathomechanism of cancer. Human papillomavirus, human immunodeficiency virus, herpes virus, and hepatitis B virus were identified as cancer-causing viruses. Several laboratory tests were developed for the detection of primary and recurrent cancers, and cancer prevention by screening methods was popularized. Sonography, computerized tomography, magnetic resonance imaging, positron emission tomography, excision of sentinel lymph nodes, and immunohistochemical techniques became routine procedures. Clinicopathologic staging and classification of tumors were standardized. Limited surgery, adjuvant and neoadjuvant chemoradiation, and the therapeutic use of monoclonal antibodies, tumor vaccines, and targeted chemotherapy became routine practice. The decline in cancer incidence and mortality demonstrated that cancer prevention and advancement in oncology are pivotal to success in the crusade against cancer. Above all, it was clearly established that the care of patients with cancer can be accomplished best in a multidisciplinary setting involving surgical oncologists, radiologists, radiation therapists, medical oncologists, surgical pathologists, and laboratory scientists. In conclusion, the 25 years from 1970 and 1995 are the high-water mark in clinical oncology, and this is the period when oncology turned from art to science. Cancer 2015;121:2480-513.

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“…A dose of 45 Gy (4500 rads) by this method is equivalent to 60 Gy (600 rads) by external beam irradiation. While attempts at limbsparing surgery using adjuvant therapies may increase the risk of local recurrence, limbsparing surgery with adjuvant radiation and chemotherapy has proved to be as effective as amputation and chemotherapy in terms of survival [22]. Local recurrence may not necessarily have an adverse effect on overall survival, particularly in low-grade lesions.…”

Section: Managementmentioning

confidence: 99%

Diagnosis and Management of Soft-Tissue Sarcomas

G¹

1994

Medical Journal Armed Forces India

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Soft-tissue sarcomas are locally aggressive tumours with a tendency to spread haematogenously, especially to the lungs. Most patients present without obvious metastases. Their management is dependent on an adequate incisional biopsy to assess the grade of the tumour. The biopsy incision must be carefully placed so as not to compromise subsequent radical excision. Of patients so treated, 20 to 30% experience local recurrence within the first 3 years postoperatively. The use of adjuvant radiotherapy decreases the incidence of local recurrence to about 15%. Patients with retroperitoneal sarcomas have a greater tendency to suffer recurrence, with disseminated disease throughout the abdomen. The overall s-year survival rate is about 50%. Patients may, however, have persistent disease or develop metastases beyond the s-year period. The optimal timing of radiation and chemotherapy remains unresolved, but multimodality treatment at least allows the advocation of limb-sparing procedures for patients with soft-tissue sarcomas. MJAFl1994; 50 : 49-55

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Control of locally advanced extremity soft tissue sarcomas by function-saving resection and brachytherapy

Cited by 111 publications

References 14 publications

Complex reconstruction of the lower extremity following sarcoma resection: a literature review

Complex reconstruction of the lower extremity following sarcoma resection: a literature review

A note from history: Landmarks in history of cancer, part 7

Diagnosis and Management of Soft-Tissue Sarcomas

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