Control of nano/molecular systems by application of macroscopic mechanical stimuli

Ariga, Katsuhiko; Mori, Taizo; Hill, Jonathan P.

doi:10.1039/c0sc00300j

Cited by 57 publications

(34 citation statements)

References 97 publications

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“…74,75 Forming stimuli-responsive materials with softly deformable structures can lead to the development of innovative and unusual functional materials such as self-powered sensors 76 and hand-operatable molecular screening systems. 77,78 In these examples, functional units and elements are structured within rational designs to create new functions that cannot be obtained by simple combinations of the properties of the original materials in their bulk states.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Forming nanomaterials as layered functional structures toward materials nanoarchitectonics

et al. 2012

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Although progress in nanotechnology is anticipated to stimulate the development of innovative materials, the areas of nanotechnology and materials science are somehow separated with little common ground in current technologies. Nanotechnology has some analytical aspects that are beneficial mainly to the nanoscopic sciences at the atom or molecular levels. Experience of these advanced techniques has only been applied in synthetic approaches to macroscopic materials in rather immature level. Forming nanomaterials into hierarchic and organized structures is a rational way of preparing advanced functional materials. Recently, one of us coined the term materials' nanoarchitectonics to express this innovation. This review focuses on recent research to develop functional materials by forming nanomaterials into organized structures, especially in well-ordered layered structural motifs. This layered nanoarchitectonics can be achieved by using the versatile technology of layer-by-layer assembly. Reassembly of bulk materials into novel layered structures through layered nanoarchitectonics has created many innovative functional materials in a wide variety of fields as can be seen in ferromagnetic nanosheets, sensors, flame-retardant coatings, transparent conductors, electrodes and transistors, walking devices, drug release surfaces, targeting drug carriers and cell culturing.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Forming nanomaterials as layered functional structures toward materials nanoarchitectonics

et al. 2012

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“…2,3 Next key step for soft matters is to create a material whose macroscopic motion is controlled by external 15 stimuli. 4 One of the strategies is to create soft materials consisting of subunits sensitive to external inputs, for instance, the photoinduced bending of polymer films consisted of azobenzene derivatives. 5,6 Another strategy is to create soft materials in which macroscopic motions of molecular assemblies 20 are actuated by small amount of molecular machines.…”

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confidence: 99%

Macroscopic motion of supramolecular assemblies actuated by photoisomerization of azobenzene derivatives

et al. 2013

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Submillimetre size self-assemblies composed of oleate and azobenzene derivatives show forceful motions such as screwtype coiling-recoiling motion by photoirradiation.In the past half century, many molecular-level machines which 10 change their molecular structure upon exposure to stimuli have been reported. 1 Nowadays, studies on macroscopic thermal motion of soft matters received attentions from the viewpoint of biomimetics. 2,3 Next key step for soft matters is to create a material whose macroscopic motion is controlled by external 15 stimuli. 4 One of the strategies is to create soft materials consisting of subunits sensitive to external inputs, for instance, the photoinduced bending of polymer films consisted of azobenzene derivatives. 5,6 Another strategy is to create soft materials in which macroscopic motions of molecular assemblies 20 are actuated by small amount of molecular machines. 7 To date, there are few reports describing macroscopic mechanical behaviour based on the latter strategy. 8 Here, we report reversible and spatially controlled macroscopic motion of oleate assembles which have submillimetre length. 25Mixtures of oleic acid (1H) and oleate (1 -) ( Fig. 1) are capable of self-assembly in aqueous solution. The morphology of the mixture depends on pH and ionic strength (I). [9][10][11] In I = 0.1 pH 8-10 aqueous media, oleates form vesicles (Fig. 2a). Between pH 7 and 8, they form several complex aggregates called "blocks" that 30 exhibit an inverted hexagonal phase 12 (Fig. 2b). In the transition region, helical and straight multilayer assemblies are coexisted with vesicles and blocks. 11 It is considered that the shape of assembly depends on the ratio of 1H and 1 -in each assembly. According to the microscopic observations of shape and 35 dynamics described in Ref. 11, the helical assemblies are sufficiently flexible to change their macroscopic helical pitch and curvature, but are also elastic because of the highly-ordered stacking structure of oleate molecules in the assembly. As demonstrated in Fig. 3, the helical assemblies exhibit a highly 40 elastic response to mechanical stress. We assumed that this softness and elasticity of the self-assembly is suitable to the spatially moving material in which motion of molecular machine should be propagated.Azobenzene derivatives 2-5 ( Fig. 1) display reversible 2-5 by addition of 70 mM KH 2 PO 4 -K 2 HPO 4 buffer solution (1.0 mL) and sonication for 20 min. A 125 µL aliquot of each suspension containing one of 2-5 was placed in a sealed microscope slide and incubated for 1 day at 25°C. All 60 azobenzene derivatives dissolved into oleate assemblies. The pH range required for formation of helical assemblies was slightly lowered by the addition of 2-5. 14 Helical assemblies were formed when pH 7.3 buffer solution was used as the dispersing medium (the pH of the dispersion was approximately 7.5); pH 65 values of buffer solution higher than 7.3 resulted in vesicle formation, and pH values lower than 7.3 led to the formation of

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“…8 Most of the manipulations, especially mechanical and electrical ones, are mediated by a molecule-solid interface. 1,4,5,7,8 …”

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confidence: 99%

Electrically Induced Conformational Change of Peptides on Metallic Nanosurfaces

Chen¹,

Cruz-Chú²,

Woodard³

et al. 2012

ACS Nano

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Surface immobilized biomolecular probes are used in many areas of biomedical research, such as genomics, proteomics, immunology, and pathology. Although the structural conformations of small DNA and peptide molecules in free solution are well studied both theoretically and experimentally, the conformation of small biomolecules bound on surfaces, especially under the influence of external electric fields, is poorly understood. Using a combination of molecular dynamics simulation and surface enhanced Raman spectroscopy, we study the external electric field-induced conformational change of dodekapeptide probes tethered to a nanostructured metallic surface. Surface-tethered peptides with and without phosphorylated tyrosine residues are compared to show that peptide conformational change under electric field is sensitive to biochemical modification. Our study proposes a highly sensitive in vitro nanoscale electro-optical detection and manipulation method for biomolecule conformation and charge at bio-nano interfaces.

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Control of nano/molecular systems by application of macroscopic mechanical stimuli

Cited by 57 publications

References 97 publications

Forming nanomaterials as layered functional structures toward materials nanoarchitectonics

Forming nanomaterials as layered functional structures toward materials nanoarchitectonics

Macroscopic motion of supramolecular assemblies actuated by photoisomerization of azobenzene derivatives

Electrically Induced Conformational Change of Peptides on Metallic Nanosurfaces

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