Control of needle hole bleeding with ethylcyanoacrylate glue (Krazy Glue)

Abstract

Needle hole bleeding from polytetrafluoroethylene (PTFE) grafts causes blood loss and prolongs vascular procedures. Past studies have shown the cyanoacrylate glues to polymerize rapidly and cause minimal tissue toxicity. This study was undertaken to evaluate the efficacy of ethyl-2-cyanoacrylate glue (Krazy Glue, KG) in obtaining prompt hemostasis in vascular anastomoses in a heparinized canine model. KG effected complete hemostasis in a significantly shorter time than oxidized cellulose and digital pressure in 18-gauge needle holes in PTFE grafts, graft to graft end-to-end anastomoses, and end of graft to side of artery anastomoses. The only limitation of KG was the development of a glue-adventitia plaque on the arterial side of some of the PTFE-artery anastomoses, causing the need for regluing. KG is an ideal agent for sealing defects in PTFE grafts.

Topical Hemostatic Agents: A Review

“…Butyl cyanoacrylate, marketed as Tissu‐Glu (isobutyl‐2‐cyanoacrylate, Ellman, Oceanside, NY) has not been approved for use in the United States. Krazy‐Glue, a short chain CA, has been described in the literature as effective for cutaneous wound closures 16 …”

REVIEW: Topical Hemostatic Agents for Dermatologic Surgery

“…Acrylates are a group of rapidly polymerizing plastics commonly found in “super‐glues.” Several acrylates have been used for hemostasis, but with the exception of Tissu‐Glu (isobutyl‐2‐cyanoacrylate) (Ellman), which is marketed for skin closure, they are not readily available for medical use. Citrin et al 12 described the use of Krazy Glue (ethyl‐2‐cyanoacrylate) to stop bleeding. Acrylic glues are applied as a drop or spray, 13 both for hemostasis and for tissue gluing.…”

A randomized, controlled, prospective trial to evaluate the haemostatic effect of Lyostypt versus Surgicel in arterial bypass anastomosis: "COBBANA" trial

“…Traditionally the problem of suture hole bleeding is managed by compression with surgical swabs and reversal heparin. Other attempts to control suture hole bleeding have also been used with various success, such as ethylcyanoacyrlate glue [ 6 ], different forms of collagen [ 7 - 10 ], oxidized cellulose [ 9 , 11 ], or gelatine sponge [ 9 ] or fibrin [ 12 , 13 ]. Another approach to topical haemostasis is the use of an agent that enhances or accelerates formation of autogenous thrombus, such as topical thrombin, which can be used in conjunction with scaffolding-type agents [ 14 , 15 ].…”