<span>In this paper the phenomenon of inverse response from systems was investigated and its transient response thoroughly analyzed. Inverse response is shown by non-minimum phase systems and some minimum phase systems. Transient analysis of these systems is lacking in literature A case study was done for a non-linear, non-minimum phase CSTR (Continuous Stirred Tank Reactor), which was identified and a novel optimized trajectory for temperature feed was synthesized, which is a non-linear dynamic constrained optimization problem solved using ACADO for a particular chemical reaction. Different control schemes were also implemented on other systems as well, which exibhit inverse responses, including model reference adaptive control. The finding shows that PID-ZN goes with the inverse response, is unable to suppress it and requires large control effort which can have serious hardware limitations. Robustness is another area where PID is lacking with these systems. MRAC shemes were able to overcome all these issues. For CSTR also, these findings hold true thus points at using advance stratigies in process control industries for maximzing product yield.</span>