Control of ovarian follicle development by TGF-β family signaling

Patton, Bethany K.; Madadi, Surabhi; Pangas, Stephanie A.

doi:10.1016/j.coemr.2021.03.001

Cited by 18 publications

(7 citation statements)

References 93 publications

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“…confirmed that the JAK–STAT signaling pathway contributes to the crosstalk between oocytes and CCs in humans using the COV434 cell line ( 49 ). Another enriched pathway is the TGF-β signaling pathway, which is reported to mediate the activation of primordial follicles, folliculogenesis, and oocyte–CC communication ( 50 ). In the Caenorhabditis elegans model, TGF-β signaling was found to regulate reproductive aging by modulating many aspects, such as oocyte morphology and quality, oocyte fertilization ability, chromosome segregation fidelity, and embryo viability and integrity ( 51 ).…”

Section: Discussionmentioning

confidence: 99%

Bioinformatic analysis confirms differences in circular RNA expression profiles of cumulus cells between patients with ovarian and peritoneal endometriosis-associated infertility

Huang

2023

Front. Endocrinol.

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Endometriosis has a detrimental effect on oocyte quality, and ovarian endometriosis (OEM) and peritoneal endometriosis (PEM) may have different effects on female fertility. Therefore, we conducted a study to explore the circular RNA (circRNA) expression profiles of cumulus cells (CCs) in patients with OEM (n = 3), PEM (n = 3), and tubal factor infertility (TFI, n = 3) using high-throughput sequencing techniques and attempted to identify common and unique circRNAs in the OEM and PEM groups. The CIRCexplorer2 program was used to identify circRNAs. Seven candidate circRNAs were validated in 30 samples using quantitative real-time polymerase chain reaction (qRT-PCR). Finally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to annotate the function of circRNA-targeted genes, which were verified by sequencing results and constructed circRNA–miRNA–mRNA networks. A total of 11833 circRNAs were identified in nine samples. The numbers of differentially expressed circRNAs between the OEM and TFI groups, PEM and TFI groups, and OEM and PEM groups were 130, 71, and 191, respectively. After taking intersections, 11 circRNAs were considered common circRNAs in the OEM and PEM groups; 39 circRNAs in the OEM group and 17 circRNAs in the PEM group were identified as unique key circRNAs. During qRT-PCR validation, hsa_circ_0003638 was significantly upregulated in the PEM group compared to that in the OEM and TFI groups. Functional analysis of circRNA-targeted genes revealed that apoptosis, PI3K-AKT, and p53 signaling pathways were enriched in the PEM–TFI comparison groups, whereas the functions of target genes involved in the JAK–STAT and TGF-β signaling pathways were enriched in the PEM–OEM comparison groups. Our findings confirmed differences in circRNA expression profiles of CCs between patients with OEM and PEM infertility and provide new insights into the different effects of various endometriosis phenotypes on oocytes.

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Section: Discussionmentioning

confidence: 99%

Bioinformatic analysis confirms differences in circular RNA expression profiles of cumulus cells between patients with ovarian and peritoneal endometriosis-associated infertility

Huang

2023

Front. Endocrinol.

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“…Elevated AMH levels reduce granulosa cell sensitivity to FSH, resulting in decreased FSH-and LH-induced aromatase mRNA expression, dysregulated E2 production and follicle development [10]. The use of AMH also protects the primordial follicle pool during chemotherapy [47]. AMH produced by granulosa cells of developing ovarian follicles protects ovarian reserve via inducing autophagy in ovaries by inhibiting FOXO3a phosphorylation [48].…”

Section: 3mentioning

confidence: 99%

Vitamin D Effects on Folliculogenesis via Ovarian Paracrine Factors

Fındık¹

2023

esmj

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Follikülogenez mekanizması çeşitli hormonları, büyüme faktörlerini ve sinyal moleküllerini içeren karmaşık bir süreçtir. Foliküler gelişim mekanizmaları üzerine gelecekteki araştırmalar, dişi reprodüktif yaşamı hakkında daha kapsamlı veriler sağlayacaktır. Vitamin D, steroidogenez yoluyla follikülogenezi etkiler. Granüloza hücrelerinde Vitamin D reseptör sinyali hormon salgılarını steroidojenik enzimler aracılığıyla düzenler. Vitamin D ve follikülogenez ile ilişkili mekanizma hala aydınlatılamamıştır. Follikülogenezin farklı evrelerinde yer alan çeşitli over kaynaklı otokrin-parakrin faktörler çalışmalarda gösterilmiştir. Bu faktörler yoluyla follikülogenez üzerindeki Vitamin D etkileri, altta yatan mekanizmayı anlamak için önemlidir. Sessiz primordial follikül aktivasyonunun inhibitörleri, Forkhead box O3a, anti-müllerian hormon, Fosfataz ve tensin homologu ve p27’dir. Bu faktörler arasından Forkhead box O3a, overde primordial folikül aktivite regülasyonu ve apoptoz mekanizmaları için önemli bir moleküldür. Primer follikülden preantral follikülün gelişiminde rol oynayan faktörler, dönüştürücü büyüme faktörü-β, büyüme ve farklılaşma faktörü 9, kemik morfogenetik protein 4,7,15 ve aktivindir. Bu derleme, steroidogenez ve ovaryan parakrin faktörler aracılığıyla VitD ve follikülogenez arasındaki ilişkiyi açıklamayı amaçlamaktadır

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“…Follicle size (Gordon, 2003;Patton et al, 2021), nutrition and feed additives (Cavalieri et al, 2018;Mohammed, 2018;Mohammed, 2019;Mohammed and Al-Hozab, 2020;Pournaghi et al, 2021;Gutiérrez-Añez et al, 2021;Saini et al, 2022), the media for maturation and their enrichments (follicular fluid, bovine serum albumin, amino acids and hormones : Mohammed, 2006;Mohammed et al, 2005;de Senna Costa et al, 2022), incubator conditions (humidity, CO2 and oxygen concentrations) were found to affect oocyte maturation (Kang et al, 2021;Yousefian et al, 2021).…”

Section: Factors Affecting Oocyte Maturationmentioning

confidence: 99%

Changes in Nucleus and Cytoplast During Oocyte Maturation: Involvement in Embryo Production

Zeidi¹,

Masruri²,

Mufarji³

et al. 2022

AAVS

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Embryo production steps either in vivo or in vitro include oocyte meiotic maturation, fertilization and culture processes. Oocyte maturation is the first step for in vivo or in vitro embryo production. Oocyte maturation appears to be a simple step, but it is a very complex process. Maturation of oocytes include several changes at the cytoplasmic and nuclear levels that makes the oocytes able to undergo fertilization, pre-implantation and post-implantation embryo development. Oocyte meiotic maturation in vivo starts after LH hormone surge whereas it starts in vitro upon release of oocyte from the ovarian follicle. Rodent oocyte maturation lasts 15-17hr. whereas that of ruminant oocyte lasts 24hr. Several factors affect on oocytes maturation either in vitro or in vivo and therefore affect development of the resulting embryos. Because of the significance of oocyte maturation stage on further embryonic development, this review aims to discuss the knowledge of oocyte maturation and its effect on further development of embryos in vivo and in vitro.

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Control of ovarian follicle development by TGF-β family signaling

Cited by 18 publications

References 93 publications

Bioinformatic analysis confirms differences in circular RNA expression profiles of cumulus cells between patients with ovarian and peritoneal endometriosis-associated infertility

Bioinformatic analysis confirms differences in circular RNA expression profiles of cumulus cells between patients with ovarian and peritoneal endometriosis-associated infertility

Vitamin D Effects on Folliculogenesis via Ovarian Paracrine Factors

Changes in Nucleus and Cytoplast During Oocyte Maturation: Involvement in Embryo Production

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