Currently, the requirements for the quality of food products, including beef and its processed products, are increasing. It is especially important to reduce various types of toxicants in regions with technogenic tension. The territory of North Ossetia -Alania is one of the most polluted regions of Russia with heavy metals due to the high concentration of industrial enterprises of non -ferrous metallurgy in the city of Vladikavkaz. The aim of the research was to study the effectiveness of the use of Chelaton and Toxi-nil Dry in the diets of fattened bulls to increase economic and biological indicators in the detoxification of heavy metals. Forty bulls of Simmental breed were selected at the age of 6 months, of which 4 groups were formed according to the analogue principle, 10 heads each. In the course of the studies for the detoxification of heavy metals in the composition of the diets of fattening bulls, Toxi-nil Dry and Chelaton adsorbents were used. It was found that the greatest productive and biological effect was ensured by joint addition of these preparations with sorption properties. Thus, when feeding a mixture of Toxi-nil Dry and Chelaton preparations, in animals of the 3rd experimental group, we could observe a significant increase in the average daily gain in live weight and a decrease in the consumption of energy and digestible protein per unit of the production. When the test preparations were co-fed, in bulls of the 3rd experimental group, the processes of rumen metabolism were optimized with the activation of proteinases, cellulases and amylases in the contents of the prestomach, which was accompanied by an increase in the digestibility ratios of crude protein, fiber and NFE. In the rumen fluid of animals of this group there was an increase in the number of ciliates, the amount of volatile fatty acids (VFA) and propionic acid. When feeding Toxi-nil Dry and Chelaton preparations, in animals of the 3rd experimental group against control analogues, blood was enriched with red blood cells, hemoglobin, total protein, glucose, calcium and phosphorus. At the same time, the joint use of the tested preparations allowed the concentration of zinc, cadmium and lead in the blood of bulls of the 3rd experimental group to be significantly reduced (P<0.05) against the control.