2019
DOI: 10.1016/j.jddst.2018.12.011
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Control of physicochemical and cargo release properties of cross-linked alginate microcapsules formed by spray-drying

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Cited by 18 publications
(33 citation statements)
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“…Images were obtained using a previously described method. 49,50 Briefly, almond particles were mounted on double-sided carbon tape and sputter coated in gold. Micrographs were obtained using a scanning electron microscope (Quattro S, Thermo-Fisher, Waltham, MA) in high vacuum mode with acceleration voltage of 5 kV.…”
Section: Analysis Of Solid Phasementioning
confidence: 99%
“…Images were obtained using a previously described method. 49,50 Briefly, almond particles were mounted on double-sided carbon tape and sputter coated in gold. Micrographs were obtained using a scanning electron microscope (Quattro S, Thermo-Fisher, Waltham, MA) in high vacuum mode with acceleration voltage of 5 kV.…”
Section: Analysis Of Solid Phasementioning
confidence: 99%
“…The formation of CLAMs uses a calcium salt such as calcium hydrogen phosphate that is 296 largely insoluble at the pH in the spray dryer feed, and only solubilizes upon volatilization of 297 ammonia to drop the pH when the feed is atomized (Jeoh-Zicari et al, 2012). In a recent study 298 however, we found that calcium concentrations maximizing cross-linking can leave residual 299 insoluble calcium in the final CLAMs product (Strobel et al, 2019b). The presence of insoluble 300 calcium salts could decrease the quality of consumer products such as topical creams; thus, an 301 alternate process was developed to use a soluble calcium salt such as calcium chloride instead.…”
Section: Cross-linked Microparticles In Water 246mentioning
confidence: 99%
“…The extent of cross-linking of CLAMs was previously shown to influence retention of cargo 412 in water (Strobel et al, 2019b). To assess the kinetics of alginate and hyaluronic acid release 413 during storage, the cross-linked microparticles were suspended in water and monitored over 120 414 min ( Figure 5).…”
Section: Characterization Of Cross-linked Microcapsules In Water 347mentioning
confidence: 99%
“…Relying on the pH-mediated dissolution of calcium during spray-dried production of CLAMs, however, has the potential to leave residual undissolved calcium salt crystals in the final product, which can be undesirable, detrimental, and unwanted for food, pharmaceuticals, and cosmetic applications. 3 Alternatively, a new process explored in this study utilizes pH-responsive chelation to control the availability of calcium ions during spray-drying. 4 The “chelate-CLAMs” process prevents ion-mediated cross-linking of alginates in the spray dryer feed by chelating soluble calcium—pH reduction of the environment beyond the p K a of the chelator in the atomized droplets in the spray dryer releases calcium ions to facilitate alginate cross-linking.…”
Section: Introductionmentioning
confidence: 99%