Control of Renin Secretion in Vivo and in Vitro in Rats: Arguments in Favour of a Precursor Form of Renin and of a Role of a Microtubular System

Banichahi, Ferrydown D.; Capponi, Alessandro M.; Pricam, C; Senarclens, C. De; Vallotton, Michel B.

doi:10.1042/cs051093s

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…Further support fo r an inactive precursor of renin is suggested by studies of renin replenishment of renin depleted kidneys of rats, in which secretory granules appear in the JGA before an increase in tissue renin (175). Acidification of extracts of kidneys of rats has been reported to increase renin more when there are numerous specific granules with paracrystalline structures and the rough endoplasmic reticulum is less well developed (7).…”

Section: Factors Affecting Inactive Renin Levels In Vivomentioning

confidence: 97%

The Renin-Angiotensin System

Reid¹,

Morris²,

Ganong³

1978

Annu. Rev. Physiol.

523

176

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Since the discovery of renin 80 years ago, there have been remarkable advances in our understanding of the renin-angiotensin system. The system as it is known today is summarized in Figure 1. Angiotensin III, the active component of the system, has several important physiological actions. The fi rst of these to be identifi ed was its pressor action, and for many years it was felt that the sole function of the renin-angiotensin system was regula tion of blood pressure. A new dimension was added in 1960 with the discovery that angiotensin II stimulates the secretion of aldosterone and is therefore in a position to exert important effects on salt and water balance. Several additional actions of angiotensin II were then discovered. It was fo und that the peptide can increase the secretion of catecholamines from the adrenal and facilitate adrenergic transmission. It also acts directly on the brain to increase blood pressure via sympathetic and parasympathetic path ways, to produce thirst, and to stimulate the secretion of vasopressin and ACTH. Through these actions, the renin-angiotensin system plays an im portant role in the regulation of blood pressure and of the volume and composition of the extracellular fl uid.Major advances have also been made in our understanding of other aspects of the renin-angiotensin system. It has become clear that the hep tapeptide metabolite of angiotensin II, [des-Aspl] angiotensin II ("angioIThe IUPAC-IUB Commission on Biochemical Nomenclature Recommenda tions (J. Dial Chem.2S0:321S) has suggested that the peptide hormones referred to in this review-angiotensin I, angiotensin II, ACTH, and growth hormone-be termed proangiotensin, angiotensin, corticotropin, and somatotropin, respectively.

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Section: Factors Affecting Inactive Renin Levels In Vivomentioning

confidence: 97%

The Renin-Angiotensin System

Reid¹,

Morris²,

Ganong³

1978

Annu. Rev. Physiol.

523

176

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The posterior pituitary of the garden dormouse (Eliomys quercinus L.)

Boudier¹,

Burlet

1978

Cell Tissue Res.

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Ultrastructural examination of the posterior pituitary of the garden dormouse (Eliomys quercinus L) was carried out at different times in the annual cycle of this hibernating rodent. Obvious differences between experimental groups have not been observed, and the results presented here must be considered as general features of the garden dormouse posterior pituitary. Neurosecretory axons and endings can be divided into two types, according to different aspects of neurosecretory granules (NSG) and microvesicles (MV). One type contains spherical NSG with homogeneous cores and round MV. In the other type, NSG have various, often elongated, shapes. Their content shows two types of crystalline structures and most of the MV have flattened aspects. As it is very unlikely that this duality in NSG is a result of an artefact of fixation, three hypotheses are presented as explanation. The duality of NSG might be related either to their hormonal content (oxytocin or vasopressin) or to their degree of maturation. Moreover, both explanations may be valid. In the species studied, pituicytes often contain concentric lamellar structures of the endoplasmic reticulum (whorls), the significance of which remains obscure.

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Dynamics of renin production by the juxtaglomerular and mesangial cells of single rat glomeruli after adrenalectomy

Федоров¹,

Perov²

1979

Bull Exp Biol Med

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Control of Renin Secretion in Vivo and in Vitro in Rats: Arguments in Favour of a Precursor Form of Renin and of a Role of a Microtubular System

Cited by 3 publications

References 3 publications

The Renin-Angiotensin System

The Renin-Angiotensin System

The posterior pituitary of the garden dormouse (Eliomys quercinus L.)

Dynamics of renin production by the juxtaglomerular and mesangial cells of single rat glomeruli after adrenalectomy

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