Control of Salmonella enteritidis phage type 4 experimental infection by fosfomycin in newly hatched chicks

Fernández, A; Lara, Carlos Alberto Luna; Loste, A.; Calvo, S. Garrido; Marca, M.C.

doi:10.1016/s0147-9571(00)00028-x

Cited by 22 publications

(11 citation statements)

References 26 publications

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“…Moreover, it has been used to treat Escherichia coli and Salmonella spp. infections in broilers (Fernández et al, 1998(Fernández et al, , 2001(Fernández et al, , 2002Prescott, 2000), one of the two domestic species where pharmacokinetics (PK) of this drug has been described (Hernández et al, 2001). In rabbits, a multiple dose regimen (60 mg/kg q6h over 3 days p.o.)…”

Section: Introductionmentioning

confidence: 99%

Intravenous and intramuscular pharmacokinetics of a single‐daily dose of disodium–fosfomycin in cattle, administered for 3 days

Sumano

Ocampo

Gutiérrez

2007

Vet Pharm & Therapeutics

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Pharmacokinetic parameters of fosfomycin in cattle were determined after administration of buffered disodium fosfomycin either intravenously (i.v.) or intramuscularly (i.m.) at a dose of 20 mg/kg/day for 3 days. Calculated concentrations at time zero and maximum serum concentrations were 34.42 and 10.18 mug/mL, respectively. The variables determined, the elimination half-life of the drug remained unchanged during the 3 days ( = 1.33 +/- 0.3 h for the i.v. route and = 2.17 +/- 0.4 h for the i.m. route). Apparent volumes of distribution suggest moderated distribution out of the central compartment (V(darea) = 673 mL +/- 27 mL/kg and V(dss) = 483 +/- 11 mL/kg). Bioavailability after i.m. administration was 74.52%. Considering fosfomycin as a time-dependent antibacterial drug, plasma concentration vs. time profiles obtained in this study, suggest that clinically effective plasma concentrations of fosfomycin could be obtained for up to 8 h following i.v. administration and approximately 10 h after i.m. injection of 20 mg/kg, for susceptible bacteria. In addition to residue studies in milk and edible tissues, a series of clinical assessments, using fosfomycin at 20 mg/kg b.i.d. or t.i.d. are warranted before this antibacterial drug should be considered for use in cattle.

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Section: Introductionmentioning

confidence: 99%

Intravenous and intramuscular pharmacokinetics of a single‐daily dose of disodium–fosfomycin in cattle, administered for 3 days

Sumano

Ocampo

Gutiérrez

2007

Vet Pharm & Therapeutics

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“…The concentration adopted referred to the need to simulate situations of low concentration contamination and not to promote lesions that could be confused with those likely promoted by organic acids. The inoculum was prepared with Salmonella Typhimurium isolated from broiler samples, as referred to by Rezende et al (2006), and was obtained according to the method described by Fernández et al (2001). Birds were fed a mash diet based on ground corn and soybean meal, with no antibiotic growth promoters or anticoccidials agents.…”

Section: Methodsmentioning

confidence: 99%

Liver Function and Bacteriology of Organs in Broiler Inoculated with Nalidixic Acid-ResistantSalmonellaTyphimurium and Treated with Organic Acids

Rocha¹,

Andrade

Gonzáles

et al. 2013

Italian Journal of Animal Science

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An experiment was carried out with 630 oneday-old chicks to evaluate the effects of organic acids when birds were experimentally inoculated with Salmonella Typhimurium. Liver damage and the persistence of the bacterium in the organs were evaluated as well. Broilers were distributed in a completely randomised experimental design in a 3×2 factorial arrangement of six treatments with seven replicates of 15 birds each. Birds were inoculated with saline solution or the bacterium via gavage at 1 day of age, or were offered a feed containing or not the organic acid blend for the period of 7 to 14 days of age. A dose of 5.0x10 2 colony-forming units (CFU)/0.5 mL of Salmonella Typhimurium was used for inoculation both via gavage and feed. The parameters evaluated are weight, liver histopathology, liver and serum biochemistry, and bacteriological analyses of the caeca, crop, spleen, and liver and heart pool. At 21 and 28 days of age, the liver of the non-inoculated groups was significantly lighter as compared to the other treatments. Birds fed organic acids presented lower bacterial isolation rates in all organs tested. Birds inoculated in the crop and treated with organic acids presented lower E. coli CFU counts (P<0.05). Birds inoculated with Salmonella presented significant changes (P<0.05) in liver enzymes, as detected by serum biochemistry, and in liver histopathology. It was concluded that organic acids effectively controlled Salmonella Typhimurium and did not cause any liver damage.

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“…Other means of prevention of Salmonella infection include treatment of food or feed compositions with chemicals such as organic acids and their salts, antibacterial agents or antibiotics like Fosfomycin and probiotics (Jung et al, 2010;Wales et al, 2010). Fosfomycin is used to prevent infection by Salmonella in poultry or chicken (Fernández et al, 2001;Ferrari et al, 2011). Yet another means of preventing infection by Salmonella is the vaccine approach where the vaccines made with live and vaccine-live, kill attenuated Salmonella (Atterbury et al, 2009).…”

Section: Methods For Prevention Of Salmonellosismentioning

confidence: 99%

Patent research in salmonellosis prevention

Santhi¹,

Sunkoji²,

Siddiram³

et al. 2012

Food Research International

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Control of Salmonella enteritidis phage type 4 experimental infection by fosfomycin in newly hatched chicks

Cited by 22 publications

References 26 publications

Intravenous and intramuscular pharmacokinetics of a single‐daily dose of disodium–fosfomycin in cattle, administered for 3 days

Intravenous and intramuscular pharmacokinetics of a single‐daily dose of disodium–fosfomycin in cattle, administered for 3 days

Liver Function and Bacteriology of Organs in Broiler Inoculated with Nalidixic Acid-ResistantSalmonellaTyphimurium and Treated with Organic Acids

Patent research in salmonellosis prevention

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