Control of steroid‐induced diabetes with supplemental chromium

Ravina, A; Slezak, Ladislav; Mirsky, Nitsa; Anderson, Richard A.

doi:10.1002/(sici)1520-670x(1999)12:4<375::aid-jtra11>3.3.co;2-i

Cited by 5 publications

(9 citation statements)

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“…For such type of deviation we are not forgiven, so several complicated diseases are seen in people using white sugar and diabetes is one of them. The regular use of fruits and vegetables, as a part of diet, maintains health but can cover the deficiencies of metallic elements in the body 12,15 . The results of Table 3 reveal that most of the sour taste plants contain reasonable amounts of chromium and zinc.…”

Section: Resultsmentioning

confidence: 99%

“…The biological activity of chromium depends on its oxidation number and the chemical form of the complex of which it is a part [9][10][11] . Glucose tolerance factor (GTF) is associated with a trivalent form of chromium and has high biological activity 10,12 (indeed Cr is one of the constituent ingredients of GTF). As age advances 13 , glucose intolerance is seen, which has been attributed to chromium deficiency 13,14 .…”

Section: Introductionmentioning

confidence: 99%

“…As age advances 13 , glucose intolerance is seen, which has been attributed to chromium deficiency 13,14 . Nanogram quantities of chromium are required in every insulin dependent system 12 . It has been reported that by acting on ribosome, chromium facilitates the incorporation of insulinstimulated amino acid into protein 11,12 .…”

Section: Introductionmentioning

confidence: 99%

“…Nanogram quantities of chromium are required in every insulin dependent system 12 . It has been reported that by acting on ribosome, chromium facilitates the incorporation of insulinstimulated amino acid into protein 11,12 . Insulin dependent diabetics excrete more chromium than the control subjects 15,16 .…”

Section: Introductionmentioning

confidence: 99%

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Analytical investigation of chromium and zinc in sweet, sour and bitter tasting fruits, vegetables and medicinal plants

Tirmizi¹,

Wattoo²,

Mazhar³

et al. 2007

Quím. Nova

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Recebido em 14/7/06; aceito em 1/2/07; publicado na web em 24/7/07 Sweet, sour and bitter tasting fruits, vegetables and medicinal plants are an important component of human diet. The role of chromium and zinc in carbohydrate metabolism for control of diabetes is highlighted in selected commodities. Average levels of chromium and zinc in sweet taste were 0.69 ± 0.48 mg kg -1 and 4.81 ± 4.31 mg kg -1 respectively with correlation of 0.545, while in sour taste the values were 22.5 ± 22.0 mg kg -1 and 24.5 ± 11.8 mg kg -1 respectively with the correlation of 0.239 and in bitter taste, 0.61 ± 0.33 mg kg -1 and 4.70 ± 3.54 mg kg -1 respectively with correlation of 0.343. Overall, sour tasting commodities were found higher in levels of chromium and zinc and are recommended as food supplement for diabeties. None of these species contain metals above the toxic level.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Analytical investigation of chromium and zinc in sweet, sour and bitter tasting fruits, vegetables and medicinal plants

Tirmizi¹,

Wattoo²,

Mazhar³

et al. 2007

Quím. Nova

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“…Each CrPic tablet contained 1800 mg, which provides 200 mg of Cr. Interestingly, in one study supplementation with CrPic has been shown to reduce fasting glucose in induced diabetes significantly from 250 to 150 mg/dL within 1-week after administration of 600 mg/day [30]. Furthermore, a study with 800 mg of Cr/day as CrPic for 8-weeks showed significant improvement in glucose tolerance compared with controls [31].…”

Section: Methodsmentioning

confidence: 99%

Effect of chromium picolinate and melatonin either in single or in a combination in high carbohydrate diet‐fed male Wistar rats

2015

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This study is designed to know the effects of chromium picolinate (CrPic) and melatonin (Mel) each alone and in a combination on high carbohydrate diet‐fed (HCD‐fed) male Wistar rats that exhibit insulin resistance (IR), hyperglycemia, and oxidative stress. Wistar rats have been categorized into five groups. Each group consisted of six male Wistar rats, control rats (group I), HCD (group II), HCD + CrPic (group III), HCD + Mel (group IV), and HCD + CrPic + Mel (group V). Insignificant differences were observed in serum levels of superoxide dismutase, nitric oxide, and zinc in group III, group IV, and group V when each group was compared with group II rats respectively. Significant differences were observed in group III, group IV, and group V when each group was compared with group II in homeostasis model assessment‐estimated IR (P < 0.05, <0.0.05, <0.05), and in the levels of blood glucose (P < 0.05, <0.0.05, <0.05), total cholesterol (P < 0.05, <0.001, <0.001), triacylglycerols (<0.05, <0.001, <0.001), high density lipoprotein cholesterol (P < 0.05, <0.001, <0.001), malondialdehyde (P < 0.05, <0.05, <0.001), catalase (P <0.05, <0.05, <0.05), glutathione (P < 0.05, <0.05, <0.05), Mel (P < 0.05, <0.05, <0.001), and copper (P < 0.05, <0.05, < 0.001). In view of these results, HCD‐fed male Wistar rats that are destined to attain IR and T2DM through diet can be prevented by giving CrPic and Mel administration in alone or in a combination. © 2015 BioFactors, 42(1):106–114, 2016

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Chromium and insulin resistance

Anderson

2003

Nutr. Res. Rev.

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Insulin resistance leads to the inability of insulin to control the utilization and storage of glucose. It is associated initially with elevated levels of circulating insulin followed by glucose intolerance which may progress to type 2 diabetes, hyperlipidaemia, hypertension, obesity and cardiovascular diseases. While the causes of these diseases are multifactorial, one nutrient that is associated with all of these abnormalities is Cr. In the presence of Cr, in a biologically active form, much lower levels of insulin are required. Modern diets, which are often high in refined carbohydrates, are not only low in Cr, but lead to enhanced Cr losses. In response to the consumption of refined carbohydrates, there is a rapid rise in blood sugar leading to elevations in insulin that cause a mobilization of Cr. Once mobilized, Cr is not reabsorbed but lost via the urine leading to decreased Cr stores. Several studies involving both human subjects and experimental animals have reported improvements in insulin sensitivity, blood glucose, insulin, lipids, haemoglobin A1c, lean body mass and related variables in response to improved Cr nutrition. However, not all studies have reported beneficial effects associated with improved Cr nutrition. Well–controlled human studies are needed to document an unequivocal effect of Cr on insulin sensitivity in human subjects. Studies need to involve a significant number of subjects with insulin resistance, glucose intolerance or early stages of diabetes, who have not been taking supplements containing Cr for at least 4 months, and involve at least 400 to 600 μg supplemental Cr daily or more. Studies should be at least 4 months to document sustained effects of supplemental Cr on insulin resistance and related variables. Cr is a nutrient and not a therapeutic agent and therefore will only be of benefit to those whose problems are due to suboptimal intake of Cr.

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Control of steroid‐induced diabetes with supplemental chromium

Cited by 5 publications

References 0 publications

Analytical investigation of chromium and zinc in sweet, sour and bitter tasting fruits, vegetables and medicinal plants

Analytical investigation of chromium and zinc in sweet, sour and bitter tasting fruits, vegetables and medicinal plants

Effect of chromium picolinate and melatonin either in single or in a combination in high carbohydrate diet‐fed male Wistar rats

Chromium and insulin resistance

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