Control of stress-induced depressive disorders by So-ochim-tang-gamibang, a Korean herbal medicine

Choi, Jung Eun; Park, Dae-Myung; Chun, Eunho; Choi, Jeong June; Seo, Ji‐Hyun; Kim, Seunghyung; Son, Jaemin; Ho, Moon; Kim, Sun Yeou; Park, Yang-Chun; Jung, In Chul; Jin, Myung

doi:10.1016/j.jep.2016.12.025

Cited by 36 publications

(25 citation statements)

References 36 publications

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“…The sequences of the realtime PCR primers were as follows: rat Bax forward: 5′-ACACCTGAGCTGACCTTG -3′, reverse: 5′-AGCCCATGAT GGTTCTGATC -3′; rat Bcl-2 forward: 5′-CATGCGACCT CTGTTTGA -3′, reverse: 5′-GTTTCATGGTCCATCCTTG -3′; rat GAPDH forward: 5′-GGAGCGAGATCCCT CCAAAAT-3′, reverse: 5′-GGCTGTTGTC ATACTTCTCAT. Relative levels of Bcl-2 and Bax were calculated using the 2 -DDCt method after normalization to GAPDH (Choi et al, 2017).…”

Section: Reverse Transcription-quantitative Pcr (Rt-qpcr)mentioning

confidence: 99%

The Protective Effect of DiDang Tang Against AlCl3-Induced Oxidative Stress and Apoptosis in PC12 Cells Through the Activation of SIRT1-Mediated Akt/Nrf2/HO-1 Pathway

et al. 2020

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Aluminum (Al) is considered a pathological factor for various neurological and neurodegenerative diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD). The neurotoxicity of aluminum can cause oxidative brain damage, trigger apoptosis, and ultimately cause irreversible damage to neurons. DiDang Tang (DDT), a classic formula within traditional Chinese medicine for promoting blood circulation and removing blood stasis and collaterals, is widely used for the treatment of stroke and AD. In this study, models of oxidative stress and apoptosis were established using AlCl 3 , and the effects of DDT were evaluated. We found that DDT treatment for 48 h significantly increased cell viability and reduced the release of lactate dehydrogenase (LDH) in AlCl 3induced PC12 cells. Moreover, DDT attenuated AlCl 3 -induced oxidative stress damage by increasing antioxidant activities and apoptosis through mitochondrial apoptotic pathways. Additionally, DDT treatment significantly activated the Sirtuin 1 (SIRT1) -mediated Akt/ nuclear factor E2 related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathways to limit AlCl 3mediated neurotoxicity. Our data indicated that DDT potently inhibited AlCl 3 -induced oxidative-stress damage and apoptosis in neural cells by activating the SIRT1-mediated Akt/Nrf2/HO-1 pathway, which provides further support for the beneficial effects of DDT on Al-induced neurotoxicity.

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Section: Reverse Transcription-quantitative Pcr (Rt-qpcr)mentioning

confidence: 99%

The Protective Effect of DiDang Tang Against AlCl3-Induced Oxidative Stress and Apoptosis in PC12 Cells Through the Activation of SIRT1-Mediated Akt/Nrf2/HO-1 Pathway

et al. 2020

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“…Herbal drug components of SOCG were obtained from Dongkyung Pharmaceutical Company (Seoul, Korea). Preparation procedure and chemical profile of SOCG have been described in our previous report [ 8 ]. Briefly, for water extraction, a total of 11 g of SOCG, which is composed of 4 g of Cyperi Rhizoma (Cyperus rotundus L.) , 2 g each of Linderae Radix (Lindera aggregata (Sims) Kosterm.…”

Section: Methodsmentioning

confidence: 99%

“…However, to determine drug efficacy, we adopted a range of lower dose as much as 50% or less for a current investigation. Our recent study also indicates that SOCG doses at 100 mg/kg and 300 mg/kg are optimal for the induction of depressive-like behavior [ 8 ]. All procedures were in strict accordance with the NIH guide for the care and use of laboratory animals and approved by the Committee on Use of Live Animals for Teaching and Research at Daejeon University (Protocol number: DJUARB2014–036, Daejeon, Korea).…”

Section: Methodsmentioning

confidence: 99%

“…In traditional Korean medicine, depression is described as a congested state of qi and thus, the therapeutic approach for depression is to refurbish its flow by using herbal drugs and acupuncture. So-o-chim-tang-gami-bang (SOCG) is a modified herbal formulation of So-o-chim-tang by substituting Aquilaria agallocha Roxb with Aucklandia lappa and supplementing Citrus aurantum and Platycodon grandifloras [ 8 ]. It is described in Dongui Bogam , a classical Korean medicinal book, that So-o-chim-tang is effective in treating abnormal regulation of qi leading to pain of internal organ, and Citrus aurantum and Platycodon grandiflorus reinforce the flow of qi to head and neck.…”

Section: Introductionmentioning

confidence: 99%

“…We have shown previously that SOCG treatment in cultured mast cells decreased the expressions of 5-hydroxytryptamine (5-HT) transporter and tryptophan hydroxylase 1 mRNAs and increased free radical-scavenging activity [ 9 ]. We further demonstrated that SOCG treatment in CRS animal model reduced corticosterone levels in the serum and induced the improvement from immobility behaviors [ 8 ]. In addition, it was reported that specific chemical ingredients or herbal components of SOCG were effective in regulating depressive- or anxiety-like behaviors in experimental animals [ 10 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Modulation of hippocampal neuronal activity by So-ochim-tang-gamibang in mice subjected to chronic restraint stress

Shin

Lee

Kim

et al. 2017

BMC Complement Altern Med

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Background So-ochim-tang-gamibang (SOCG) is a decoction formula which has been used to improve mental activity in traditional Korean medicine. The present study was performed to evaluate whether the treatment of SOCG was involved in activating hippocampal neurons in mice which were subjected to chronic restraint stress (CRS).MethodsMice were subjected to CRS for 2 weeks to induce depressive-like behaviors. SOCG was orally administered for the same period. mRNA expression in the hippocampus was analyzed by RT-PCR. Levels of serotonin receptor 5-HT1AR in the hippocampus were determined by western blotting and by immunofluorescence staining in coronal brain sections. Cultured neurons were prepared from the dorsal root ganglia (DRG) in mice to examine the effects of CRS and SOCG treatment on neurite outgrowth. Depressive-like behaviors of experimental animals were measured by open field test (OFT) and forced swimming test (FST).ResultsmRNA levels of serotonin 1A and 1B receptors (5-HT1AR and 5-HT1BR) were decreased in the hippocampus of CRS animals and increased by SOCG treatment. Signals of 5-HT1AR protein in CA3 pyramidal cells were decreased by CRS but elevated back to levels in control animals after SOCG treatment. Phospho-Erk1/2 protein in CA3 cells showed similar pattern of changes as in 5-HT1AR, suggesting coordinated regulation after SOCG treatment in CRS animals. Axonal growth-associated protein GAP-43 levels were also decreased by CRS and then increased by SOCG treatment. In vivo administration of SOCG improved neurite outgrowth of primary DRG neurons from CRS animals and also increased 5-HT1AR protein signals. Behavioral tests of open field and forced swimming showed that immobility time periods were significantly decreased by SOCG treatment.ConclusionsOur data suggest that SOCG treatment may increase synaptic responsiveness to serotonergic neuronal inputs by upregulating 5-HT1AR in the hippocampal neurons.

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Rapid antidepressant‐like effect of Fructus Aurantii depends on cAMP‐response element binding protein/Brain‐derived neurotrophic facto by mediating synaptic transmission

Zhang

Chen

et al. 2020

Phytotherapy Research

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Several studies reported the relative antidepressant effects of Fructus Aurantii (FRA) with repeated treatment, the rapid antidepressant effects of FRA and the underlying mechanisms remained unclear. We, therefore, examined the rapid antidepressant actions of FRA in behavioral tests in mice and tested the underlying molecular mechanisms. We found FRA, like ketamine, reversed the behavioral deficits both in lipopolysaccharide(LPS)‐induced and learned helplessness (LH) models at 1 day after a single administration. FRA was also capable of increasing the expressions of protein kinase A/cAMP‐response element‐binding protein/brain‐derived neurotrophic factor (PKA/CREB/BDNF) signaling in hippocampus. Consistent with ketamine, FRA up‐regulated the expressions of GABAergic receptor (GAD67) and glutamatergic receptor 1 (GluR1) in mouse hippocampus both exposed to LPS and LH. Moreover, synaptic proteins such as postsynaptic density‐95 (PSD95) and synapsin1 were also up‐regulated by a single dose of FRA both in LH and LPS models, like ketamine. Finally, metadoxine (an antagonist of CREB) inhibited the antidepressant effects of FRA in tail suspension test (TST) and forced swimming test (FST) in LPS‐induced mice, which also blocked the phosphorylation of CREB and the expressions of neurotransmitters and synaptic molecules. Therefore, FRA had rapid antidepressant effects, which depended on PKA/CREB/BDNF pathway, subsequently regulated the downstream synaptic transmission.

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Control of stress-induced depressive disorders by So-ochim-tang-gamibang, a Korean herbal medicine

Cited by 36 publications

References 36 publications

The Protective Effect of DiDang Tang Against AlCl3-Induced Oxidative Stress and Apoptosis in PC12 Cells Through the Activation of SIRT1-Mediated Akt/Nrf2/HO-1 Pathway

The Protective Effect of DiDang Tang Against AlCl3-Induced Oxidative Stress and Apoptosis in PC12 Cells Through the Activation of SIRT1-Mediated Akt/Nrf2/HO-1 Pathway

Modulation of hippocampal neuronal activity by So-ochim-tang-gamibang in mice subjected to chronic restraint stress

Rapid antidepressant‐like effect of Fructus Aurantii depends on cAMP‐response element binding protein/Brain‐derived neurotrophic facto by mediating synaptic transmission

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