Control of Structure Topology and Spatial Distribution of Biomacromolecules in Protein@ZIF-8 Biocomposites

Abstract

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Encapsulation, Visualization and Expression of Genes with Biomimetically Mineralized Zeolitic Imidazolate Framework‐8 (ZIF‐8)

“…Zeolitic imidazolate frameworks (ZIFs) are members of the MOF family and are made of zinc ions coordinated by imidazole rings to form topological isomorphs of zeolites . They have demonstrated biocompatibility, biodegradability, protection, and potential applications in antitumor therapy, protection of biomarkers, and encapsulation of therapeutics . Several nano MOFs, including ZIFs, have been used successfully to deliver small interfering ribonucleic acids (siRNAs) and oligonucleotides, and encapsulation of proteins and cells has also been reported .…”

“…The utilization of water washed plGFP@ZIF‐8 for cellular expression and gene delivery could also have an impact on uptake and efficiency. Since separate polymorphs of plGFP@ZIF‐8 can result on washing with water in place of ethanol tailoring of synthesis conditions to deliver the therapeutic gene in accordance to the requirements of individual cases, forms the basis of our future studies. It is expected that this approach will result in a promising gene delivery agent that protects and maintains functional activity of DNA and affords customized expression of genes leading to specifically designed persistence of therapeutic levels in vivo .…”

Polymer Networks: From Plastics and Gels to Porous Frameworks

“…[202] ZIF-8 is synthesized from Zn(NO 3 ) 2 and 2-methylimidazole. [203] Its junctions are ZnN 4 -based tetrahedra (Note:Nhere represents coordinating nitrogen atoms of imidazolate ligands) connected through bifunctional 2-methylimidazolate linkers (Figure 11 C), where the metalimidazolate-metal angle is similar to the 1458 8 SiÀOÀSi angle in zeolites.Z IF-8 possesses al arge pore diameter of 11.4 yet as mall aperture size of 3.4 (i.e., the limiting size for amolecule to enter the pores), [204] though the aperture of ZIF-8isflexible and can accommodate guest molecules larger than its size. [205] TheBET surface area of ZIF-8 was measured to be 1630 m 2 g À1 .…”

Polymernetzwerke: Von Kunststoffen und Gelen zu porösen Gerüsten

“…Seine Vernetzungsgruppen sind auf ZnN 4 basierende Tetraeder (Anmerkung: N verkörpert hier koordinierende Stickstoffatome von Imidazolat‐Liganden) die über bifunktionelle 2‐Methylimidazolat‐Linker verbunden sind (Abbildung C), wobei der Metall‐Imidazolat‐Metall‐Winkel mit dem Si‐O‐Si‐Winkel von 145° in Zeolithen vergleichbar ist. ZIF‐8 besitzt einen großen Porendurchmesser (11.4 Å), aber eine kleine Porenöffnung (3.4 Å) als begrenzende Größe für das Eindringen eines Moleküls in die Poren . Die Porenöffnungen von ZIF‐8 sind jedoch flexibel und können Gastmoleküle, die größer als sie sind, aufnehmen .…”

“…ZIF-8 besitzt einen großen Porendurchmesser (11.4 ), aber eine kleine Porençffnung (3.4 )a ls begrenzende Grçße fürd as Eindringen eines Moleküls in die Poren. [204] Die Porençffnungen von ZIF-8s ind jedoch flexibel und kçnnen Gastmoleküle,d ie grçßer als sie sind, aufnehmen. [205] Die gemessene BET-Oberfläche von ZIF-8 betrug 1630 m 2 g À1 .…”