Control of the enantioselectivity of the bioreduction with immobilized bakers' yeast in a hexane solvent system

Microbial reduction of ethyl acetoacetate to ethyl (R)-3-hydroxybutyrate in an ionic liquid containing system

“…The results show that the co-substrate not only affects the reduction yield but also the product e.e., and even changes the configuration of the product. Similar result was also reported in the literature [28]. Different co-substrates probably caused the inactivation of the R-enzymes and/or activation of the S-enzymes to different degree.…”