Control of the in vivo Biodistribution of Hybrid Nanoparticles with Different Poly(ethylene glycol) Coatings

Faure, Anne-Charlotte; Dufort, Sandrine; Josserand, Véronique; Perriat, Pascal; Coll, Jean‐Luc; Roux, S.; Tillement, Olivier

doi:10.1002/smll.200900563

Cited by 124 publications

(107 citation statements)

References 30 publications

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“…Similarly, PEGylation of magnetic gadolinium oxide coated in a fluorescent silane shell has also been reported. [99] A comparison of four different PEGs PEG 250 -COOH, PEG 2000 -COOH, PEG 2000 -OCH 3 , and PEG 2000 -NH 2 showed that the gadolinium oxide coated with methoxy terminated PEG 2000 demonstrated the longest blood circulation time and greatest accumulation in tumor. Changing the methoxy group to amine or carboxy functionality resulted in an increased accumulation of NPs in the liver and spleen as a result of the higher surface charge in these compounds.…”

Section: Pegylation Of Iron Oxide Using Silane Chemistrymentioning

confidence: 99%

PEGylated Inorganic Nanoparticles

et al. 2011

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Application of inorganic nanoparticles in diagnosis and therapy has become a critical component in the targeted treatment of diseases. The surface modification of inorganic oxides is important for providing diversity in size, shape, solubility, long-term stability, and attachment of selective functional groups. This Minireview describes the role of polyethylene glycol (PEG) in the surface modification of oxides and focuses on their biomedical applications. Such a PEGylation of surfaces provides "stealth" characteristics to nanomaterials otherwise identified as foreign materials by human body. The role of PEG as structure-directing agent in synthesis of oxides is also presented.

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Section: Pegylation Of Iron Oxide Using Silane Chemistrymentioning

confidence: 99%

PEGylated Inorganic Nanoparticles

et al. 2011

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“…6,56 Particles with varying corona layers throughout the sample and particularly particles with a large number of layers may see effects in affinity, 6 functionality, 6,57 and steric hindrance. 58,59 Therefore, we establish a method to use PSD measurements to estimate the variation in the protein layering within the sample. In a set of images, each interrogation area exhibits a different diffusion coefficient value.…”

Section: E Comparing Psd With Theoretical Predictionsmentioning

confidence: 99%

Physical characterization of nanoparticle size and surface modification using particle scattering diffusometry

Clayton¹,

Salameh

Wereley³

et al. 2016

Biomicrofluidics

281

166

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As the field of colloidal science continues to expand, tools for rapid and accurate physiochemical characterization of colloidal particles will become increasingly important. Here, we present Particle Scattering Diffusometry (PSD), a method that utilizes dark field microscopy and the principles of particle image velocimetry to measure the diffusivity of particles undergoing Brownian motion. PSD measures the diffusion coefficient of particles as small as 30 nm in diameter and is used to characterize changes in particle size and distribution as a function of small, labelfree, surface modifications of particles. We demonstrate the rapid sizing of particles using three orders-of-magnitude less sample volume than current standard techniques and use PSD to quantify particle uniformity. Furthermore, PSD is sensitive enough to detect biomolecular surface modifications of nanometer thickness. With these capabilities, PSD can reliably aid in a wide variety of applications, including colloid sizing, particle corona characterization, protein footprinting, and quantifying biomolecule activity. Published by AIP Publishing. [http://dx

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“…From the fit of a Gaussian function to the histogram, the average diameter of the particles was determined to 3.6 ± 0.9 nm. The size distribution is narrow, and the sizes of the obtained nanoparticles appear small enough to be considered for in vivo MRI applications [19].…”

mentioning

confidence: 99%

Growth of Gd2O3 nanoparticles inside mesoporous silica frameworks

Ballem

Söderlind

Nordblad

et al. 2013

Microporous and Mesoporous Materials

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Gadolinium oxide (Gd 2 O 3 ) nanoparticles with very small size and narrow size distribution were synthesized by infiltration of Gd(NO 3 ) 3 ·6H 2 O as an oxide precursor into the pores of SBA-15 mesoporous silica using a wet-impregnation technique. High resolution transmission electron microscopy and X-ray diffraction show that during the hydrothermal treatment of the precursor at 550 °C, gadolinium oxide nanoparticles inside the silica pores are formed. Subsequent dissolution of the silica framework in aqueous NaOH resulted in well dispersed nanoparticles with an average diameter of 3.6 ± 0.9 nm. If GdCl 3 ·6H 2 O is used as precursor, GdOCl is formed instead of Gd 2 O 3 . The Gd 2 O 3 nanoparticles showed a weak antiferromagnetic behaviour, as expected.

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Control of the in vivo Biodistribution of Hybrid Nanoparticles with Different Poly(ethylene glycol) Coatings

Cited by 124 publications

References 30 publications

PEGylated Inorganic Nanoparticles

PEGylated Inorganic Nanoparticles

Physical characterization of nanoparticle size and surface modification using particle scattering diffusometry

Growth of Gd2O3 nanoparticles inside mesoporous silica frameworks

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