Saturation gain-length product during short-wavelength plasma lasing Appl. Phys. Lett. 101, 081105 (2012) Laser induced avalanche ionization in gases or gas mixtures with resonantly enhanced multiphoton ionization or femtosecond laser pulse pre-ionization Phys. Plasmas 19, 083508 (2012) A new scheme for stigmatic x-ray imaging with large magnification Rev. Sci. Instrum. 83, 10E527 (2012) Additional information on AIP Conf. Proc.Abstract. We overview our recent results on experimental observation of nuclear process in hot dense plasma created by focusing of femtosecond laser pulses with intensity below 10 17 W/cm 2 on the target surface. In the first part of the paper we introduce special technique of target properties modification allowing us to increase both hot electron temperature and ion temperature. We successfully applied this technique to rise ion temperature in D-enriched Ti target up to 10-20 keV, thus observing 2.5 MeV neutron yield at intensity of as small as 10 16 W/cm 2 . We further discuss some possibilities arising from our recent experiments on low energy nuclear level excitation in hot dense plasma created by femtosecond laser pulses of moderate intensity.