We review our recent work on design and fabrication of microstructured waveguides (WG) in birefringent nonlinear crystal, z-cut lithium niobate (LiNbO 3 ), and describe simulation approaches to both design and optimisation of such structures. We also review our experimental results achieved by using direct fs laser inscription in such hosts using high repetition rate femtosecond oscillator system. Refractive index (RI) contrasts as high as -0.0127 have been demonstrated for individual tracks. The experimental relations between RI contrast and track dimensions were used for optimisation of depressed cladding waveguides in such hosts. We demonstrate that the spectral range for such microstructured waveguides in LiNbO 3 can be extended up to the long-wavelength end of the transparency of material.