Control of urinary bladder function with devices: successes and failures

Gaunt, Robert A.; Procházka, A.

doi:10.1016/s0079-6123(05)52011-9

Cited by 97 publications

(58 citation statements)

References 182 publications

(270 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A limited number of treatments have been reported for restoring the control of the bladder 6, 7, 8, 9. The use of available oral drugs show limited clinical benefits,10, 11 and have numerous undesired side effects 12.…”

Section: Introductionmentioning

confidence: 99%

A 3D Printed Implantable Device for Voiding the Bladder Using Shape Memory Alloy (SMA) Actuators

et al. 2017

View full text Add to dashboard Cite

Underactive bladder or detrusor underactivity (DU) is defined as a reduction of contraction strength or duration of the bladder wall. Despite the serious healthcare implications of DU, there are limited solutions for affected individuals. A flexible 3D printed implantable device driven by shape memory alloys (SMA) actuators is presented here for the first time to physically contract the bladder to restore voluntary control of the bladder for individuals suffering from DU. This approach is used initially in benchtop experiments with a rubber balloon acting as a model for the rat bladder to verify its potential for voiding, and that the operating temperatures are safe for the eventual implantation of the device in a rat. The device is then implanted and tested on an anesthetized rat, and a voiding volume of more than 8% is successfully achieved for the SMA‐based device without any surgical intervention or drug injection to relax the external sphincter.

show abstract

Section: Introductionmentioning

confidence: 99%

A 3D Printed Implantable Device for Voiding the Bladder Using Shape Memory Alloy (SMA) Actuators

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Transection of the sacral dorsal roots ( posterior rhizothomy) performed in combination with SARS to increase bladder capacity and compliance and improve voiding efficiency is effective, 53 but irreversibly eliminates reflex erection, reflex micturition and any remaining pelvic sensation. 36,54 Brindley reported that out of 12 of the early patients with reflex incontinence, all became fully continent following sacral posterior rhizotomies, and this is now standard practice with SARS implantation. 55 In persons with supra-sacral SCI, SARS coupled with posterior rhizotomy produced voiding volumes greater than 200 mL in 18/21 patients and decreased postvoid residual volumes below 50 mL in 15/21 patients.…”

Section: Finetech-brindley Bladder Control Systemmentioning

confidence: 99%

Electrical stimulation for the treatment of lower urinary tract dysfunction after spinal cord injury

McGee

Amundsen²,

Grill³

2015

The Journal of Spinal Cord Medicine

View full text Add to dashboard Cite

Electrical stimulation for bladder control is an alternative to traditional methods of treating neurogenic lower urinary tract dysfunction (NLUTD) resulting from spinal cord injury (SCI). In this review, we systematically discuss the neurophysiology of bladder dysfunction following SCI and the applications of electrical stimulation for bladder control following SCI, spanning from historic clinical approaches to recent pre-clinical studies that offer promising new strategies that may improve the feasibility and success of electrical stimulation therapy in patients with SCI. Electrical stimulation provides a unique opportunity to control bladder function by exploiting neural control mechanisms. Our understanding of the applications and limitations of electrical stimulation for bladder control has improved due to many pre-clinical studies performed in animals and translational clinical studies. Techniques that have emerged as possible opportunities to control bladder function include pudendal nerve stimulation and novel methods of stimulation, such as high frequency nerve block. Further development of novel applications of electrical stimulation will drive progress towards effective therapy for SCI. The optimal solution for restoration of bladder control may encompass a combination of efficient, targeted electrical stimulation, possibly at multiple locations, and pharmacological treatment to enhance symptom control.

show abstract

“…Individuals with SCI who do not respond well to medications or want to reduce their dependency on catheterization may benefit from bladder neuroprostheses. 68 In general, patients must have a bladder that can contract and intact motor nerves to the bladder to be eligible for these devices. 69 Two commercial bladder neuroprostheses are available to patients with non-neurogenic bladder dysfunction, who have intact spinal reflex circuits that control the bladder.…”

Section: Bladder Neuroprosthesesmentioning

confidence: 99%

Neuroprosthetic technology for individuals with spinal cord injury

Collinger¹,

Foldes

Bruns

et al. 2013

The Journal of Spinal Cord Medicine

View full text Add to dashboard Cite

Context: Spinal cord injury (SCI) results in a loss of function and sensation below the level of the lesion. Neuroprosthetic technology has been developed to help restore motor and autonomic functions as well as to provide sensory feedback. Findings: This paper provides an overview of neuroprosthetic technology that aims to address the priorities for functional restoration as defined by individuals with SCI. We describe neuroprostheses that are in various stages of preclinical development, clinical testing, and commercialization including functional electrical stimulators, epidural and intraspinal microstimulation, bladder neuroprosthesis, and cortical stimulation for restoring sensation. We also discuss neural recording technologies that may provide command or feedback signals for neuroprosthetic devices. Conclusion/clinical relevance: Neuroprostheses have begun to address the priorities of individuals with SCI, although there remains room for improvement. In addition to continued technological improvements, closing the loop between the technology and the user may help provide intuitive device control with high levels of performance.

show abstract

Control of urinary bladder function with devices: successes and failures

Cited by 97 publications

References 182 publications

A 3D Printed Implantable Device for Voiding the Bladder Using Shape Memory Alloy (SMA) Actuators

A 3D Printed Implantable Device for Voiding the Bladder Using Shape Memory Alloy (SMA) Actuators

Electrical stimulation for the treatment of lower urinary tract dysfunction after spinal cord injury

Neuroprosthetic technology for individuals with spinal cord injury

Contact Info

Product

Resources

About