The work presents an analysis of the Gorlov helical turbine (GHT) design using both computational fluid dynamics (CFD) simulations and response surface methodology (RSM). The RSM method was applied to investigate the impact of three geometric factors on the turbine’s power coefficient (CP): the number of blades (N), helix angle (γ), and aspect ratio (AR). Central composite design (CCD) was used for the design of experiments (DOE). For the CFD simulations, a three-dimensional computational domain was established in the Ansys Fluent software, version 2021R1 utilizing the k-ω SST turbulence model and the sliding mesh method to perform unsteady flow simulations. The objective function was to achieve the maximum CP, which was obtained using a high-correlation quadratic mathematical model. Under the optimum conditions, where N, γ, and AR were 5, 78°, and 0.6, respectively, a CP value of 0.3072 was achieved. The optimal turbine geometry was validated through experimental testing, and the CP curve versus tip speed ratio (TSR) was determined and compared with the numerical results, which showed a strong correlation between the two sets of data.