Contrôle inhibiteur du comportement d'agression interspécifique du rat: système sérotoninergique du raphéet afférences olfactives

Differential behavioral effects of lesions of the medial or dorsal raphe nuclei in rats: Open field and pain-elicited aggression.

“…Previous studies utilizing combined lesions of the dorsal and median raphe nuclei have reported increased aggression (Grant, Coscina, Grossman, & Freedman, 1973;Vergnes, Mack, & Kempf, 1974) and increased activity (Kostowski, Giacalone, Garattini, & Valzelli, 1968;Lorens, Sorensen, & Yunger, 1971). The present study demonstrates that these behavioral changes may be differentially attributable to lesions of the dorsal nucleus in the case of increased aggressiveness and of the median nucleus in the case of increased open-field activity.…”

“…Several points concerning the increase in pain-elicited aggression following dorsal lesions deserve mentioning. Grant et al (1973) and Vergnes et al (1974) reported increased muricidal aggression following midbrain raphe lesions, while the present study is apparently the first to examine pain-elicited aggression following raphe lesions. The literature is somewhat mixed concerning pharmacologically produced depletion of brain serotonin and pain-elicited aggression, with Eichelman and Thoa (1973) and Conner, Stolk, Barchas, Dement, and Levine (1970) finding no increase and Ellison and Bresler (1974) reporting an approximately 100% increase.…”

Aggressiveness by Isolation and Brain Serotonin Turnover Changes in Different Strains of Mice

“…These consist in the observations that: (a) isolated-aggressive mice require longer than normal mice to reach a 50% increase in brain 5-HT after monoamineoxidase blockade ( Valzelli, 1966;Welch and Welch, 1971); (b) forebrain 5-HT is reduced in isolated-aggressive mice (Lagerspetz et al, 1967); (c) brain 5-H1AA is decreased in isolated-aggressive mice (Garattini et al, , 1969Welch and Welch, 1968); (d) brain 5-HT turnover is reduced in isolated-aggressive mice (Garattini et al, , 1969Giacalone et al, 1968;Essman, 1968Essman, , 1969Essman, , 1971Valzelli, 1971 );(e) isolated-aggres sive mice have decreased tryptophan-hydroxy lase activity in septal area (Segal et al, 1973); (f) brain tryptophan is reduced in isolatedaggressive mice (Miller et al, 1978;Pacliter et al, 1978); (g) inhibition of brain 5-HT synthe sis by p-chloro-N-methylamphetamine (PCMA) increases isolation-induced aggression in mice (Hodge and Butcher, 1974); (h) brain 5-HT depletion induced by p-chlorophenylalanine (PCPA) is accompanied by increased irritability and sometimes overt aggressiveness in normal rats (Koe and Weissman, 1966) and by facilita tion or induction of muricidal behavior in isolated or brain lesioned rats (Di Cliiara et al, 1971;Popova et al, 1975;Sheard, 1969); (i) olfactory bulb ablation decreases amygdaloid 5-HT to about 85% of baseline value and induces muricidal behavior in laboratory rats (Karli et al, 1969(Karli et al, , 1972Sakata et al, 1975); (j) lesion of midbrain raphe area, a neural region from which most of tire serotonergic projections arise, lowers forebrain serotonin, and to varying extents either increases or in duces muricidal aggression in rats (Banerjee, 1974;Breeze et al, 1974;Grant et al, 1973;Popova et al, 1975;Vergnes et al, 1974) and facilitates the onset of aggressiveness due to isolation in mice (Valzelli, 1977); (k) isolationinduced muricidal behavior in rats is accompa nied by a decrease of brain 5-HT turnover …”