The eastern boundary of the Southern Cascades (Hat Creek Graben region), California, USA, is an extensively faulted volcanic corridor between the Cascade Range and Modoc Plateau. The morphology of the region is a result of plate motions associated with different tectonic provinces, faulting, and recurring volcanic activity, making it an ideal place to study the interrelationship between tectonics, volcanoes, and geomorphology. We use the morphometry and spatial distribution of volcanoes and their interaction with regional structures to understand how long term regional deformation can affect volcano evolution. A database of volcanic centers and structures was created from interpretations of digital elevation models. Volcanic centers were classified by morphological type into cones, sub-cones, shields and massifs. A second classification by height separated the larger and smaller edifices, and revealed an evolutionary trend. Poisson Nearest Neighbor analysis showed that bigger volcanoes are spatially dispersed while smaller ones are clustered. Using volcano centroid locations, about 90 lineaments consisting of at least three centers within 6 km of one another were found, revealing that preferential north-northwest directed pathways control the transport of magma from the source to the surface, consistent with the strikes of the major fault systems. Most of the volcano crater and collapse scar openings are perpendicular to the north northwest-directed maximum horizontal stress, expected for extensional environments with dominant normal faulting. Early in the history of a volcano or volcano cluster, melt propagates to the surface using the easiest and most efficient pathway, mostly controlled by the pre-existing normal faults and near-surface stress fields, as indicated by the pervasive vent alignments. Volcano growth continues to be dependent on the regional structures as indicated by the opening directions, suggesting structural control on the growth of the volcanic edifices. The results present a particularly well-defined case in which extension of a volcanic region is accommodated mostly by faulting, and only partly by intrusion to form volcanoes. This is attributed to a low magma supply rate.