Controled Ovarian Stimulation with Urinary Gonadotrophins and Recombinant Gonadotrophins in Current Practice

Mehedințu, Claudia; Brătilă, Elvira; Brînduşe, Lăcrămioara Aurelia; Cîrstoiu, Monica Mihaela; Berceanu, Costin; Bordea, Alina Elena; Comandaşu, Diana; Veliscu, Andreea Carp; Bratu, Ovidiu Gabriel; Sava, Cristian; Bumbu, Adrian Gheorghe

doi:10.37358/rc.18.12.6803

Cited by 3 publications

(3 citation statements)

References 25 publications

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“…An adequate vitamin D level during pregnancy ensures an optimum vitamin D level to the fetus, resulting in a normal bone development due to the fact that vitamin D crosses the placenta and creates deposits especially during the 3 rd trimester. A vitamin D deficit in women during pregnancy is most prevalent in high risk populations [9]. Low levels of vitamin D in pregnancy seems to be associated with an increased risk for gestational diabetes mellitus, preeclampsia and fetal growth restriction and in the long term, for deficient skeletal homeostasis, congenital rickets, early bone fractures and immune deficiencies [10][11][12].…”

Section: Biochemical Mechanismsmentioning

confidence: 99%

The Prevalence of Vitamin D Defficiency and its Obstetrical Effects. A prospective study on Romanian patients

Bohîlțea¹,

Zugravu²,

Neacşu³

et al. 2019

Rev. Chim.

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The birth, growth, development, reproduction and senescence under physiological conditions can be achieved without diminishing the role of other important aspects that influence them, only with the support of an optimal diet that is a fundamental requirement nowadays, considering that the health and the nutritional status are in a permanent interdependence. The effects of inadequate nutrition reflect on the expression of genes, influencing the development of certain diseases in childhood and adulthood. Knowing the phases of the gestation period in which the need of certain nutrients is increased, and their absence has the most serious impact on fetal growth and development, allows for the adoption in due time of concrete preventive rules. Disorders associated with lipid malabsorption, such as celiac disease, Crohn�s disease, pancreatic insufficiency, cystic fibrosis and cholestatic disease, are associated with low serum levels of 5-hydroxyvitamin D. Vitamin D deficiency in the newborn can express as deficient skeletal homeostasis, congenital rickets and fractures in the early days of life. A low level of vitamin D during pregnancy seems to increase the risk of preeclampsia, intrauterine growth restriction and gestational diabetes, and in the longer term it seems to affect the bone, immune system and general status. The prevalence of hypovitaminosis D is increasing globally, and the effects on pregnancy and neonatal outcome of the vitamin D deficiency and supplementation are a topical issue, which is currently under investigation.

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Section: Biochemical Mechanismsmentioning

confidence: 99%

The Prevalence of Vitamin D Defficiency and its Obstetrical Effects. A prospective study on Romanian patients

Bohîlțea¹,

Zugravu²,

Neacşu³

et al. 2019

Rev. Chim.

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“…Bisphenol A (BPA) is another phenol associated with precocious puberty in girls, which is often used to make household products [4,19]. Animal studies have demonstrated estrogenic properties for BPA, this compound being associated with earlier onset of puberty in female rats, leading to a precocious vaginal opening [12,20,21].…”

Section: Phenolsmentioning

confidence: 99%

“…GnRH leads to a rise in pulsatile secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland. Gonadotropin release is a trigger for the gonads, the final result being the onset of ovulatory menstrual cycles [1,3,4].…”

mentioning

confidence: 99%

Chemicals in Personal Care Products Tied to Early Puberty in Girls

Petca¹,

Boț²,

Petca³

et al. 2019

Rev. Chim.

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Precocious puberty is defined as the onset of menarche before 9 years of age, or the appearance of secondary sex characteristics before 8 years of age. It is associated with many psychosocial disturbances and adverse health outcomes such as: cardiovascular disease, shorter adult stature, an increased risk of type 2 diabetes and breast cancer. There is a general tendency to a progressive decrease in age of reaching puberty, specifically the onset of thelarche and menarche, girls being 10 times more affected than boys. This actual tendency can be explained by the increasing prevalence of childhood obesity and also by increasing environmental exposure to endocrine disruptor chemicals in household and personal care products.Phenols, phthalates, parabens and other compounds, such as polybrominated biphenyls and diethylstilbestrol are associated with precocious onset of puberty in girls, in case of in-utero or peripubertal exposure. These chemicals are frequently found in toothpaste, cosmetics, soups, shampoos, perfumes and other personal care products, interfering with sex hormones and puberty timing. This is why pregnant women should be more aware and avoid products based on these chemicals.

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Assessing the Role of Lipopolysaccharide (LPS) Receptor (CD14) in Septic Cardiomyopathy: The Value of Immunohistochemical Diagnostics

et al. 2022

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Sepsis-induced myocardial dysfunction (SIMD) is one of the major predictors of morbidity and mortality of sepsis. A high percentage of patients with SIMD develop a status similar to cardiogenic shock. A high level of bacterial lipopolysaccharide (LPS) associated with an overexpression of CD14 acts as the trigger for the release of a broad spectrum of cytokines. Our study aimed to understand the correlation between septic cardiomyopathy and CD14 immunohistochemical expression. The study included 29 patients who died of septic shock. Increased values of membranous CD14 and soluble CD14 in the heart tissue were correlated with adverse patient evolution. A high cellular expression of CD14 was noted in the study group vs. the control group (p = 0.0013). Therefore, a close positive association between the amount of LPS related to sCD14 and the cellular expression of mCD14 is probable. By extrapolation, we suggest that a large amount of sCD14 detected in the cardiac tissue will activate the mCD14–TRL4–LBP–LPS complex, which in turn will induce an inadequate immune response, resulting in heart damage proportional to the amount of LPS. CD14 could represent a valuable marker for septic cardiomyopathy; thus, apoptosis of cardiomyocytes could be foreseen by its high value.

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Controled Ovarian Stimulation with Urinary Gonadotrophins and Recombinant Gonadotrophins in Current Practice

Cited by 3 publications

References 25 publications

The Prevalence of Vitamin D Defficiency and its Obstetrical Effects. A prospective study on Romanian patients

The Prevalence of Vitamin D Defficiency and its Obstetrical Effects. A prospective study on Romanian patients

Chemicals in Personal Care Products Tied to Early Puberty in Girls

Assessing the Role of Lipopolysaccharide (LPS) Receptor (CD14) in Septic Cardiomyopathy: The Value of Immunohistochemical Diagnostics

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