When a two-qubit system is initially maximally-entangled, two independent decoherence channels, one per qubit, would greatly reduce the entanglement of the two-qubit system when it reaches its stationary state. We propose a method on how to minimize such a loss of entanglement in open quantum systems. We find that the quantum entanglement of general two-qubit systems with controllable parameters can be protected by tuning both the single-qubit parameters and the twoqubit coupling strengths. Indeed, the maximum fidelity Fmax between the stationary entangled state, ρ∞, and the maximally-entangled state, ρm, can be about 2/3 ≈ max{tr(ρ∞ρm)} = Fmax, corresponding to a maximum stationary concurrence, Cmax, of about 1/3 ≈ C(ρ∞) = Cmax. This is significant because the quantum entanglement of the two-qubit system can be protected, even for a long time. We apply our proposal to several types of two-qubit superconducting circuits, and show how the entanglement of these two-qubit circuits can be optimized by varying experimentallycontrollable parameters.