Controllable growth of drug-encapsulated metal-organic framework (MOF) on porphyrinic MOF for PDT/chemo-combined therapy

Recent advances and prospects of metal–organic frameworks in cancer therapies

“…Therefore, PDT treatment may be combined with chemotherapy to increase the therapeutic effect of PDT. In Liu's study, 72 a doxorubicin (DOX)-encapsulated zeolite imidazole salt framework (ZIF-8) was assembled on the surface of Zr( iv )-based porphyrin MOF (PCN) to synthesize PCN@D/ZIF, as shown in Fig. 7a.…”

Zn-Dipicolylamine-Based ROS-Responsive Bola-Lipid Nanoparticles for Efficient Protein Delivery and Tumor Immunotherapy

“…Among them, liposomes are regarded as an important carrier system for antigen delivery since the lipid structure may be rationally designed and altered to provide the liposomes specific properties such as tunable size and charge, facile loading for both hydrophilic and hydrophobic drugs, and coordinating delivery of antigens and other stimulatory molecules to APCs or T cells. 9,31,32 Unlike commonly used cationic lipid molecules containing one cationic headgroup, bola-amphiphiles, also called bola- lipids, are dumbbell-shaped molecules consisting of one or two hydrophobic chains with two polar headgroups at both ends. Bola-lipids may facilitate the formation of monolayer membrane instead of bilayer membrane.…”

“…Therefore, they were widely used in the treatment of a variety of diseases. − However, the hydrophilicity and tertiary structure of proteins make them difficult to freely cross the cell membrane with high hydrophobic character, which seriously hinders the development of cytosolic protein delivery. − To overcome the limitation, researchers have developed a variety of nanocarrier systems, such as polymers, − liposomes, − gold nanoparticles, , and hydrogels, for effective protein delivery. Among them, liposomes are regarded as an important carrier system for antigen delivery since the lipid structure may be rationally designed and altered to provide the liposomes specific properties such as tunable size and charge, facile loading for both hydrophilic and hydrophobic drugs, and coordinating delivery of antigens and other stimulatory molecules to APCs or T cells. ,, …”

Effective Enrichment of Phosphopeptides Using Magnetic Polyoxometalate-Based Metal–Organic Frameworks

“…As a novel porous material, metal–organic frameworks (MOFs) have features of regular porous structure, tunable properties, and high surface area. − In MOFs, a periodic skeleton structure is formed by a combination of organic ligands and metal ions. The unsaturated metal ions can provide affinity sites for phosphoprotein adsorption. , However, MOFs still have some drawbacks, such as poor stability and single adsorption site, restricting the further application in proteomics. , Therefore, there is still an urgent need to design a new pattern of MOF-based porous materials for proteomic analysis.…”

“…11,12 However, MOFs still have some drawbacks, such as poor stability and single adsorption site, restricting the further application in proteomics. 13,14 Therefore, there is still an urgent need to design a new pattern of MOF-based porous materials for proteomic analysis.…”