Controllable Release of Povidone-Iodine from Networked Pectin@Carboxymethyl Pullulan Hydrogel

Abstract

Povidone-iodine (PI) is a common antiseptic reagent which is used for skin infections and wound healing. The control release of PI is quite important to heal the deep and intense wounds. Herein, the preparation of biodegradable pectin@carboxymethyl pullulan (Pe@CMP) hydrogel was carried out and applied for controllable release of PI. CMP was synthesized by interaction of monochloroacetic acid with pullulan at different ratios. The Pe@CMP hydrogel was then prepared by crosslinking of pectin with CMP in presence of glutaraldehyde as cross linker. After carboxymethylation, COOH contents were enlarged to be 24.2–51.2 mmol/kg and degree of substitution was 0.44–0.93. The rheological properties of Pe@CMP hydrogel were enlarged by increment of pectin ratio. Swelling ratio in water (16.0–18.0%) was higher than that of artificial sweat (11.7–13.2%). Pe@CMP hydrogel containing 20% pectin, exhibited the lowest release and 57.7% from PI was released within 360 min. The biological activity of the released PI was monitored to be highly efficient. The kinetic of release was fitted well to the first ordered reaction and Higuchi models. The mechanism of release was explained by the swelling of hydrogel. The networked structure of hydrogel was opened by swelling and PI was released from the outer pores followed by inner pores, achieving the controllable release.

Synthesis and Characterization of Slow-Release Fertilizer Hydrogel Based on Hydroxy Propyl Methyl Cellulose, Polyvinyl Alcohol, Glycerol and Blended Paper

“…Cellulose is mainly found in high amount in different plant sources where it is cheap, abundantly available and biodegradable [ 19 ]. A lot of effort has been made to replace synthetic polymers with cellulose derivatives, which are used in controlled release for drugs [ 20 , 21 , 22 ], removal of pharmaceutical pollutants in waste water [ 23 , 24 ], dye removal in waste water [ 25 , 26 ] and agrochemicals after crosslinking [ 27 ]. Hydroxy propyl methyl cellulose (HPMC) is an odourless, tasteless, white to slightly off white fibrous or granular free flowing powder.…”

An Overview on the Recent Advances in the Treatment of Infected Wounds: Antibacterial Wound Dressings

“…Antiseptic reagents are a suitable alternative to antibiotics due to their wider range of action. [ 232 ] For example, one of the antiseptic reagents is polyvinyl pyrrolidone‐bound iodine (PI). It is composed of iodine binding to polyvinylpyrrolidone and is soluble in water.…”

The Utilisation of Gelatin Biopolymer in Textile Wet Processing

“…Hydrogels are widely employed in biomedical applications due to their efficient control over swelling kinetics and high-water holding capacity. From a biomedical standpoint, self-healing and in situ forming hydrogels are important [27][28][29][30][31].…”