Controlled aggregation of methylene blue in silica–methylene blue nanocomposite for enhanced 1O2 generation

Saita, Satoshi; Anzai, Maho; Mori, Nanase; Kawasaki, Hideya

doi:10.1016/j.colsurfa.2021.126360

Cited by 15 publications

(14 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There are no peaks derived from crystalline silica structure. The pattern is characteristic of amorphous silica with a broad diffraction peak near 2 θ = 22°, which is consistent with typical amorphous silica [ 16 , 36 , 37 ]. The SEM image of RH NPs shows the size and shape were not controlled during their preparation, but the RH NPs consisted of fused NPs with small sizes of ca.…”

Section: Resultssupporting

confidence: 65%

“…ABDA can react irreversibly with 1 O 2 , which causes a decrease in the ABDA absorption at 379 nm. An aqueous suspension of RB-RH NPs (1.8 mL, ~ RB absorbance of 0.1 at 665 nm) was mixed with ABDA in DMF (0.5 mM, 0.2 mL), and the final concentration of ABDA was adjusted to be 50 μM according to the references [ 16 ]. The RB absorbance of around 0.05 at 570 nm was selected to obtain dispersed RB-RH NP solution.…”

Section: Methodsmentioning

confidence: 99%

“…Silica NPs (SiOx NPS) are chemically inert and have high water dispersibility and surface modification capability. Various type’s silica supports have been proposed for PDT applications, such as mesoporous SiOx NPs with the pore-integrated PSs [ 13 – 15 ], aggregated SiOx NPs with the pore-integrated PSs [ 16 , 17 ], and covalently or physically bound complexes of PSs and SiOx NPs. [ 18 – 23 ].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Rose bengal-decorated rice husk-derived silica nanoparticles enhanced singlet oxygen generation for antimicrobial photodynamic inactivation

et al. 2023

Self Cite

View full text Add to dashboard Cite

Rice husks are well known for their high silica content, and the RH-derived silica nanoparticles (RH NPs) are amorphous and biocompatible; therefore, they are suitable raw materials for biomedical applications. In this study, rose bengal-impregnated rice husk nanoparticles (RB-RH NPs) were prepared for their potential photosensitization and 1 O 2 generation as antimicrobial photodynamic inactivation. RB is a halogen-xanthene type’s photosensitizer showing high singlet oxygen efficiency, and the superior photophysical properties are desirable for RB in the antimicrobial photodynamic inactivation of bacteria. To enhance the binding of anionic RB to RH NPs, we conducted cationization for the RH NPs using polyethyleneimine (PEI). The control of the RB adsorption state on cationic PEI-modified RH NPs was essential for RB RH-NP photosensitizers to obtain efficient 1 O 2 generation. Minimizing RB aggregation allowed highly efficient 1 O 2 production from RB-RH NPs at the molar ratio of RB with the PEI, X RB/PEI. = 0.1. The RB-RH NPs have significant antimicrobial activity against Streptococcus mutans compared to free RB after white light irradiation. The RB-RH NP-based antimicrobial photodynamic inactivation can be employed effectively in treating Streptococcus mutans for dental applications. Graphical abstract Supplementary Information The online version contains supplementary material available at 10.1007/s10853-023-08194-z.

show abstract

Section: Resultssupporting

confidence: 65%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Rose bengal-decorated rice husk-derived silica nanoparticles enhanced singlet oxygen generation for antimicrobial photodynamic inactivation

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…In addition, photodynamic therapy (PDT) is another laser-based therapy in which photosensitizers accumulate in tumours and produce reactive oxygen species (ROS) under specific laser irradiation to kill tumour cells [ 12 , 13 ]. PDT, as a rapidly developing treatment technology, has shown many advantages in the clinical treatment of various tumours, with the characteristics of reduced invasiveness, fewer side effects, and lower drug resistance [ 14 ]. Methylene blue (MB) is a heterocyclic aromatic dye soluble in ethanol or water belonging to the thiophenazine family that acts as a highly efficient photosensitizer for PDT.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of methylene blue-loaded ovalbumin/polypyrrole nanoparticles for enhanced phototherapy-triggered antitumour immune activation

Mao

et al. 2022

J Nanobiotechnol

View full text Add to dashboard Cite

Background Phototherapy-triggered immunogenic cell death (ICD) rarely elicits a robust antitumour immune response, partially due to low antigen exposure and inefficient antigen presentation. To address these issues, we developed novel methylene blue-loaded ovalbumin/polypyrrole nanoparticles (MB@OVA/PPY NPs) via oxidative polymerization and π–π stacking interactions. Results The as-prepared MB@OVA/PPY NPs with outstanding photothermal conversion efficiency (38%) and photodynamic properties were readily internalized into the cytoplasm and accumulated in the lysosomes and mitochondria. Upon 808 nm and 660 nm laser irradiation, the MB@OVA/PPY NPs not only ablated tumour cells by inducing local hyperthermia but also damaged residual tumour cells by generating a large amount of reactive oxygen species (ROS), finally triggering the release of many damage-associated molecular patterns (DAMPs). Moreover, the MB@OVA/PPY NPs synergized with DAMPs to promote the maturation and improve the antigen presentation ability of DCs in vitro and in vivo. Conclusions This work reported a PPY NPs-based nanoplatform to encapsulate the therepeutic proteins and absorb the functional molecules for combination therapy of tumours. The results demonstrated that the prepared MB@OVA/PPY NPs could be used as effective nanotherapeutic agents to eliminate solid tumours and trigger a powerful antitumour immune response.

show abstract

“…In addition, the photodynamic therapy (PDT) is another laser-based therapy in which the photosensitizer accumulated in tumors and produce reactive oxygen species (ROS) under the speci c laser irradiation and then kill tumor cells [12][13]. PDT, as a rapidly developing treatment technology, has shown many advantages in the clinical treatment of various tumors, with the characteristics of less invasive, less side effects, and less drug resistance [14]. Methylene blue (MB) is a soluble heterocyclic aromatic dye in ethanol or water belonging to the thiophenazine family, and acts as high-e cient photosensitizer of PDT.…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Methylene Blue Loaded Ovalbumin/Polypyrrole Nanoparticles for Enhanced Phototherapy-Triggered Antitumor Immune Activation

Mao

et al. 2021

Preprint

View full text Add to dashboard Cite

Phototherapy-triggered immunogenic cell death (ICD) hardly elicit robust antitumor immune response partially due to low antigen exposure and inefficient antigen presentation. To address these issues, we developed a novel methylene blue loaded ovalbumin/ polypyrrole nanoparticles (MB@OVA/PPY NPs) via oxidative polymerization and π-π stacking reaction. The as-prepared MB@OVA/PPY NPs with outstanding photothermal conversion efficiency (38%) and photodynamic property could be readily internalized into cytoplasm and accumulated in lysosome and mitochondria. Upon 808 nm and 660 nm laser irradiation, the MB@OVA/PPY NPs not only ablated the tumor cells by inducing local hyperthermia, but also damaged residual tumor cells by generating a large amount of reactive oxygen species (ROS), finally triggered the release of large amount of damage associated molecular patterns (DAMPs). Moreover, the MB@OVA/PPY NPs synergized with DAMPs promoted thematuration and improved antigen presentation ability of DCs in virto and vivo. This work demonstrated that the MB@OVA/PPY NPs could be used as effective nanotherapeutic agents for eliminating the solid tumor and triggering powerful antitumor immune response.

show abstract

Controlled aggregation of methylene blue in silica–methylene blue nanocomposite for enhanced 1O2 generation

Cited by 15 publications

References 30 publications

Rose bengal-decorated rice husk-derived silica nanoparticles enhanced singlet oxygen generation for antimicrobial photodynamic inactivation

Rose bengal-decorated rice husk-derived silica nanoparticles enhanced singlet oxygen generation for antimicrobial photodynamic inactivation

Fabrication of methylene blue-loaded ovalbumin/polypyrrole nanoparticles for enhanced phototherapy-triggered antitumour immune activation

Fabrication of Methylene Blue Loaded Ovalbumin/Polypyrrole Nanoparticles for Enhanced Phototherapy-Triggered Antitumor Immune Activation

Contact Info

Product

Resources

About