Controlled analysis of factors associated with insufficient sample on outpatient endometrial biopsy

Bakour, Shagaf H.; Khan, Khalid S.; Gupta, Janesh

doi:10.1111/j.1471-0528.2000.tb11627.x

Cited by 53 publications

(49 citation statements)

References 6 publications

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“…This is because insufficient tissue samples are generally taken to mean absence of pathological findings. 45,46 We also excluded intrauterine polyps and fibroids as part of a sensitivity analysis to examine whether the presence of these focal lesions affected estimates of diagnostic accuracy.…”

Section: Quantitative Data Synthesismentioning

confidence: 99%

Accuracy of Hysteroscopy in the Diagnosis of Endometrial Cancer and Hyperplasia

Clark

Voit²,

Gupta³

et al. 2002

JAMA

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353

197

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Section: Quantitative Data Synthesismentioning

confidence: 99%

Accuracy of Hysteroscopy in the Diagnosis of Endometrial Cancer and Hyperplasia

Clark

Voit²,

Gupta³

et al. 2002

JAMA

Self Cite

353

197

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“…These findings replicate other published studies which have demonstrated that age and menopausal status may be factors of importance for sample adequacy. 67,68 In the moderate-risk (premenopausal) women for whom insertion was possible, nulliparity was for both Tao brush and Pipelle samplers an important factor in the outcome 'inadequate sample' (p < 0.001 for both), in addition to its effect on insertion. These findings suggest that the use of Tao brush may be advantageous in the investigation of postmenopausal women, but not for moderate-risk women.…”

Section: Performance Of Investigative Modalitymentioning

confidence: 99%

Evaluation of abnormal uterine bleeding: comparison of three outpatient procedures within cohorts defined by age and menopausal status

Critchley

Warner²,

Lee³

et al. 2004

Health Technol Assess

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“…device is generally considered a negative result 9 . Information on the number of women recruited into the study and those whose outcome data were known was also sought from the manuscripts.…”

mentioning

confidence: 99%

Accuracy of outpatient endometrial biopsy in the diagnosis of endometrial cancer: a systematic quantitative review

Clark

2002

BJOG: An International Journal of Obstetrics and Gynaecology

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Objective To determine the accuracy of outpatient endometrial biopsy in diagnosing endometrial cancer in women with abnormal uterine bleeding.Design A systematic quantitative review of published research.Methods Studies were selected if accuracy of outpatient endometrial biopsy was estimated compared with a reference standard. Diagnostic accuracy was determined by pooled likelihood ratios for positive and negative test results. There were 1013 subjects in 13 diagnostic evaluations reported in 11 primary studies.Results A positive test result on outpatient biopsy diagnosed endometrial cancer with a pooled likelihood ratio of 66.48 (95% CI 30.04 -147.13) while a negative test result had a pooled likelihood ratio of 0.14 (95% CI 0.08 -0.27). The post test probability of endometrial cancer was 81.7% (95% CI 59.7% -92.9%) for a positive test and 0.9% (95% CI 0.4% -2.4%) for a negative test.Conclusion Outpatient endometrial biopsy has a high overall accuracy in diagnosing endometrial cancer when an adequate specimen is obtained. A positive test result is more accurate for ruling in disease than a negative test result is for ruling it out. Therefore, in cases of abnormal uterine bleeding where symptoms persist despite negative biopsy, further evaluation will be warranted.

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Controlled analysis of factors associated with insufficient sample on outpatient endometrial biopsy

Cited by 53 publications

References 6 publications

Accuracy of Hysteroscopy in the Diagnosis of Endometrial Cancer and Hyperplasia

Accuracy of Hysteroscopy in the Diagnosis of Endometrial Cancer and Hyperplasia

Evaluation of abnormal uterine bleeding: comparison of three outpatient procedures within cohorts defined by age and menopausal status

Accuracy of outpatient endometrial biopsy in the diagnosis of endometrial cancer: a systematic quantitative review

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